期刊
NATURE REVIEWS MICROBIOLOGY
卷 7, 期 9, 页码 677-683出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nrmicro2184
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- National Institute of General Medical Sciences [GM34821, GM66174]
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R01AI081059] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM034821, R37GM034821, R01GM066174] Funding Source: NIH RePORTER
Intracellular lipid transport is poorly understood. Genetic studies to identify lipid-transport factors are complicated by the essentiality of many lipids, whereas biochemical and cell biology approaches aiming to determine localization and mechanisms of lipid transport are often challenged by the lack of adequate technology. Here, we review the epic history of how different approaches, technological advances and ingenuity contributed to the recent discovery of a multi-protein pathway that transports lipopolysaccharide across the envelope of Gram-negative bacteria.
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