期刊
NATURE REVIEWS MICROBIOLOGY
卷 7, 期 3, 页码 215-225出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nrmicro2087
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资金
- Australian Research Council
- Australian National Health and Medical Research Council
- University of Queensland
If DNA is the information of life, then proteins are the machines of life - but they must be assembled and correctly folded to function. A key step in the protein-folding pathway is the introduction of disulphide bonds between cysteine residues in a process called oxidative protein folding. Many bacteria use an oxidative protein-folding machinery to assemble proteins that are essential for cell integrity and to produce virulence factors. Although our current knowledge of this machinery stems largely from Escherichia coli K-12, this view must now be adjusted to encompass the wider range of disulphide catalytic systems present in bacteria.
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