期刊
NATURE REVIEWS MICROBIOLOGY
卷 6, 期 9, 页码 699-708出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nrmicro1928
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- NCI NIH HHS [CA057973, R01 CA057973-10, R01 CA057973-15, R01 CA057973, R01 CA057973-08, R01 CA057973-11, R01 CA057973-09, R01 CA057973-14, R01 CA057973-16, R01 CA057973-12, R01 CA057973-13] Funding Source: Medline
- NIAID NIH HHS [R01 AI072613-02, R01 AI072613-03, R01 AI075099-01A1, AI072613, AI075099, R01 AI072613, R01 AI072613-01, R01 AI075099, R01 AI075099-02] Funding Source: Medline
viruses of the Flaviviridae family, including hepatitis c, dengue and bovine viral diarrhoea, are responsible for considerable morbidity and mortality worldwide. recent advances in our understanding of virion assembly have uncovered commonalities among distantly related members of this family. We discuss the emerging hypothesis that physical virion components are not alone in forming the infectious particle, but that non-structural proteins are intimately involved in orchestrating morphogenesis. Pinpointing the roles of Flaviviridae proteins in virion production could reveal new avenues for antiviral therapeutics.
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