期刊
NATURE REVIEWS GENETICS
卷 15, 期 11, 页码 749-763出版社
NATURE PORTFOLIO
DOI: 10.1038/nrg3803
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资金
- ERC (ArchAdapt)
- Austrian Science Funds (FWF) [W1225]
- Austrian Science Fund (FWF) [W1225] Funding Source: Austrian Science Fund (FWF)
The analysis of polymorphism data is becoming increasingly important as a complementary tool to classical genetic analyses. Nevertheless, despite plunging sequencing costs, genomic sequencing of individuals at the population scale is still restricted to a few model species. Whole-genome sequencing of pools of individuals (Pool-seq) provides a cost-effective alternative to sequencing individuals separately. With the availability of custom-tailored software tools, Pool-seq is being increasingly used for population genomic research on both model and non-model organisms. In this Review, we not only demonstrate the breadth of questions that are being addressed by Pool-seq but also discuss its limitations and provide guidelines for users.
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