期刊
NATURE REVIEWS GENETICS
卷 16, 期 2, 页码 113-126出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nrg3853
关键词
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资金
- Deutsche Forschungsgemeinschaft [GRK 1360]
- DEEP programme [01KU1216D]
Post-transcriptional gene regulation (PTGR) of mRNA turnover, localization and translation is mediated by microRNAs (mi-RNAs) and RNA-binding proteins (RBPs). These regulators exert their effects by binding to specific sequences within their target mRNAs. Increasing evidence suggests that competition for binding is a fundamental principle of PTGR. Not only can mi-RNAs be sequestered and neutralized by the targets with which they interact through a process termed ` sponging', but competition between binding sites on different RNAs may also lead to regulatory crosstalk between transcripts. Here, we quantitatively model competition effects under physiological conditions and review the role of endogenous sponges for PTGR in light of the key features that emerge.
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