期刊
NATURE REVIEWS GENETICS
卷 15, 期 6, 页码 394-408出版社
NATURE PORTFOLIO
DOI: 10.1038/nrg3683
关键词
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资金
- Academia Sinica
- US National Science Foundation [MCB-1243608]
RNA-directed DNA methylation (RdDM) is the major small RNA-mediated epigenetic pathway in plants. RdDM requires a specialized transcriptional machinery that comprises two plant-specific RNA polymerases - Pot IV and Pot V - and a growing number of accessory proteins, the functions of which in the RdDM mechanism are only partially understood. Recent work has revealed variations in the canonical RdDM pathway and identified factors that recruit Pot IV and Pol V to specific target sequences. RdDM, which transcriptionally represses a subset of transposons and genes, is implicated in pathogen defence, stress responses and reproduction, as well as in interallelic and intercellular communication.
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