期刊
NATURE REVIEWS GENETICS
卷 14, 期 8, 页码 572-584出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nrg3484
关键词
-
资金
- US National Institutes of Health (NIH) [GM57071, 84364, 86217]
- NIH, National Cancer Institute, Center for Cancer Research
Transcriptional regulation is achieved through combinatorial interactions between regulatory elements in the human genome and a vast range of factors that modulate the recruitment and activity of RNA polymerase. Experimental approaches for studying transcription in vivo now extend from single-molecule techniques to genome-wide measurements. Parallel to these developments is the need for testable quantitative and predictive models for understanding gene regulation. These conceptual models must also provide insight into the dynamics of transcription and the variability that is observed at the single-cell level. In this Review, we discuss recent results on transcriptional regulation and also the models those results engender. We show how a non-equilibrium description informs our view of transcription by explicitly considering time-and energy-dependence at the molecular level.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据