期刊
NATURE REVIEWS GENETICS
卷 14, 期 2, 页码 113-124出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nrg3366
关键词
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资金
- US National Institutes of Health [R01GM076007, R01GM093182]
- Packard Fellowship
The human Y chromosome is intriguing not only because it harbours the master-switch gene that determines gender but also because of its unusual evolutionary history. The Y chromosome evolved from an autosonne, and its evolution has been characterized by massive gene decay. Recent whole-genome and transcriptome analyses of Y chromosomes in humans and other primates, in Drosophila species and in plants have shed light on the current gene content of the Y chromosome, its origins and its long-term fate. Furthermore, comparative analysis of young and old Y chromosomes has given further insights into the evolutionary and molecular forces triggering Y-chromosome degeneration and into the evolutionary destiny of the Y chromosome.
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