期刊
NATURE REVIEWS GENETICS
卷 13, 期 6, 页码 406-420出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nrg3227
关键词
-
资金
- Boehringer Ingelheim
- US Defense Advanced Research Projects Agency
- US National Institutes of Health
- US National Science Foundation
Synthetic gene circuits are designed to program new biological behaviour, dynamics and logic control. For all but the simplest synthetic phenotypes, this requires a structured approach to map the desired functionality to available molecular and cellular parts and processes. In other engineering disciplines, a formalized design process has greatly enhanced the scope and rate of success of projects. When engineering biological systems, a desired function must be achieved in a context that is incompletely known, is influenced by stochastic fluctuations and is capable of rich nonlinear interactions with the engineered circuitry. Here, we review progress in the provision and engineering of libraries of parts and devices, their composition into large systems and the emergence of a formal design process for synthetic biology.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据