期刊
NATURE REVIEWS GENETICS
卷 11, 期 5, 页码 356-366出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nrg2760
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资金
- US National Institutes of Health [DK062370, GM081441, HG000376, HL090564]
- Burroughs Wellcome Fund
- Alfred P. Sloan Foundation
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R01HL090564] Funding Source: NIH RePORTER
- NATIONAL HUMAN GENOME RESEARCH INSTITUTE [R01HG000376, R29HG000376] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [R56DK062370, U01DK062370, R01DK062370] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM081441] Funding Source: NIH RePORTER
Genome-wide association (GWA) studies have identified a large number of SNPs associated with disease phenotypes. As most GWA studies have been performed in populations of European descent, this Review examines the issues involved in extending the consideration of GWA studies to diverse worldwide populations. Although challenges exist with issues such as imputation, admixture and replication, investigation of a greater diversity of populations could make substantial contributions to the goal of mapping the genetic determinants of complex diseases for the human population as a whole.
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