期刊
NATURE REVIEWS GENETICS
卷 11, 期 12, 页码 819-829出版社
NATURE RESEARCH
DOI: 10.1038/nrg2883
关键词
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资金
- Prostate Cancer Foundation
- Doris Duke Charitable Foundation
- Burroughs Welcome Foundation
Genomic rearrangements are associated with many human genomic disorders, including cancers. It was previously thought that most genomic rearrangements formed randomly but emerging data suggest that many are nonrandom, cell type-, cell stage- and locus-specific events. Recent studies have revealed novel cellular mechanisms and environmental cues that influence genomic rearrangements. In this Review, we consider the multitude of influences on genomic rearrangements by grouping these influences into four categories: proximity of chromosomal regions in the nucleus, cellular stress, inappropriate DNA repair or recombination, and DNA sequence and chromatin features. The synergy of these triggers can poise a cell for rearrangements and here we aim to provide a conceptual framework for understanding the genesis of genomic rearrangements.
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