期刊
NATURE REVIEWS GENETICS
卷 10, 期 2, 页码 122-133出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nrg2509
关键词
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资金
- Biotechnology and Biological Sciences Research Council [BBF0235451, BBSB16550, BBC0082001]
- Biotechnology and Biological Sciences Research Council [BB/F023545/1] Funding Source: researchfish
- BBSRC [BB/F023545/1] Funding Source: UKRI
Two related developments are currently changing traditional approaches to computational systems biology modelling. First, stochastic models are being used increasingly in preference to deterministic models to describe biochemical network dynamics at the single-cell level. Second, sophisticated statistical methods and algorithms are being used to fit both deterministic and stochastic models to time course and other experimental data. Both frameworks are needed to adequately describe observed noise, variability and heterogeneity of biological systems over a range of scales of biological organization.
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