期刊
NATURE REVIEWS GENETICS
卷 10, 期 3, 页码 184-194出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nrg2537
关键词
-
资金
- Wellcome Trust
- EC funded GABRIEL project
- French Ministry of Research and Higher Education
- National Institutes Health
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [U01HL084729] Funding Source: NIH RePORTER
- NATIONAL HUMAN GENOME RESEARCH INSTITUTE [R01HG002651] Funding Source: NIH RePORTER
Variation in gene expression is an important mechanism underlying susceptibility to complex disease. The simultaneous genome-wide assay of gene expression and genetic variation allows the mapping of the genetic factors that underpin individual differences in quantitative levels of expression (expression QTLs; eQTLs). The availability of systematically generated eQTL information could provide immediate insight into a biological basis for disease associations identified through genome-wide association (GWA) studies, and can help to identify networks of genes involved in disease pathogenesis. Although there are limitations to current eQTL maps, understanding of disease will be enhanced with novel technologies and international efforts that extend to a wide range of new samples and tissues.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据