期刊
NATURE REVIEWS GENETICS
卷 10, 期 4, 页码 264-269出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nrg2516
关键词
-
资金
- National Institutes of Health [CA098233, DK58845]
The brisk discovery of novel inherited disease markers by genome-wide association (GWA) studies has raised expectations for predicting disease risk by analysing multiple common alleles. However, the statistics used during the discovery phase of research (such as odds ratios or p values for association) are not the most appropriate measures for evaluating the predictive value of genetic profiles. We argue that other measures - such as sensitivity, specificity, and positive and negative predictive values - are more useful when proposing a genetic profile for risk prediction.
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