期刊
NATURE REVIEWS GENETICS
卷 10, 期 5, 页码 290-294出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nrg2539
关键词
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资金
- National Institutes of Health [R37CA25235]
- American Cancer Society
- Howard Hughes Medical Institute early career award
- NATIONAL CANCER INSTITUTE [R37CA025235] Funding Source: NIH RePORTER
The cancerous cellular state is associated with multiple epigenetic alterations, but elucidating the precise order of such alterations during tumorigenic progression and their contributions to the transformed phenotype remains a significant challenge in cancer biology. Here we discuss recent findings on how viral oncoproteins exploit specific epigenetic processes to coerce normal cells to replicate when they should remain quiescent-a hallmark of cancer. These findings may highlight roles of epigenetic processes in normal biology and shed light on epigenetic events occurring along the path of non-viral neoplastic transformation.
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