期刊
NATURE REVIEWS GENETICS
卷 10, 期 9, 页码 651-U77出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nrg2617
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资金
- National Cancer Institute [U01 CA84244]
- US Department of Energy [DE-FG02-03ER63630]
- Barbara Bass Bakar Chair of Cancer Genetics
Genetic studies of cancer susceptibility have shown that most heritable risk cannot be explained by the main effects of common alleles. This may be due to unknown gene-gene or gene-environment interactions and the complex roles of many genes at different stages of cancer. Studies using mouse models of cancer suggest that methods that integrate genetic analysis and genomic networks with knowledge of cancer biology can help to extend our understanding of heritable cancer susceptibility.
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