期刊
NATURE REVIEWS GENETICS
卷 9, 期 10, 页码 764-775出版社
NATURE RESEARCH
DOI: 10.1038/nrg2430
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资金
- National Institutes of Health [U01 MH61915, R01 MH078024]
- Silvio O. Conte Center grant [P50 MH074924]
- NATIONAL INSTITUTE OF MENTAL HEALTH [P50MH074924, R01MH078024, U01MH061915] Funding Source: NIH RePORTER
Circadian cycles affect a variety of physiological processes, and disruptions of normal circadian biology therefore have the potential to influence a range of disease-related pathways. The genetic basis of circadian rhythms is well studied in model organisms and, more recently, studies of the genetic basis of circadian disorders has confirmed the conservation of key players in circadian biology from invertebrates to humans. In addition, important advances have been made in understanding how these molecules influence physiological functions in tissues throughout the body. Together, these studies set the scene for applying our knowledge of circadian biology to the understanding and treatment of a range of human diseases, including cancer and metabolic and behavioural disorders.
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