期刊
NATURE REVIEWS GENETICS
卷 9, 期 8, 页码 619-631出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nrg2380
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资金
- Medical Research Council [G0400959, G0600776, G0300662B] Funding Source: researchfish
- Biotechnology and Biological Sciences Research Council Funding Source: Medline
- Medical Research Council [G0600776, G0400959] Funding Source: Medline
- MRC [G0600776, G0400959] Funding Source: UKRI
Hereditary defects in the repair of DNA damage are implicated in a variety of diseases, many of which are typified by neurological dysfunction and/or increased genetic instability and cancer. Of the different types of DNA damage that arise in cells, single-strand breaks (SSBs) are the most common, arising at a frequency of tens of thousands per cell per day from direct attack by intracellular metabolites and from spontaneous DNA decay. Here, the molecular mechanisms and organization of the DNA-repair pathways that remove SSBs are reviewed and the connection between defects in these pathways and hereditary neurodegenerative disease are discussed.
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