期刊
NATURE REVIEWS GENETICS
卷 9, 期 3, 页码 179-191出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nrg2270
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资金
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [Z01HL005801, ZIAHL005801] Funding Source: NIH RePORTER
- Intramural NIH HHS Funding Source: Medline
Over two metres of DNA is packaged into each nucleus in the human body in a manner that still allows for gene regulation. This remarkable feat is accomplished by the wrapping of DNA around histone proteins in repeating units of nucleosomes to form a structure known as chromatin. This chromatin structure is subject to various modifications that have profound influences on gene expression. Recently developed techniques to study chromatin modifications at a genome-wide scale are now allowing researchers to probe the complex components that make up epigenomes. Here we review genome-wide approaches to studying epigenomic structure and the exciting findings that have been obtained using these technologies.
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