IBD IN 2012 Pathogenesis and management of IBO-thinking outside the box

In 2012, important advances were made in understanding the pathogenesis of IBD-the Immunochip project increased the number of known IBD loci to 163, and underscored the common susceptibility to infectious diseases. With regard to management of IBD, novel non-anti-TNF agents have shown efficacy in phase II and III trials. Vermeire, S. & Rutgeerts, R Nat. Rev. Gastroenterol. Hepatol. 10, 67-69 (2013); published online 8 January 2013; doi:10.1038/nrgastro.2012.241