期刊
NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
卷 10, 期 11, 页码 686-690出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nrgastro.2013.171
关键词
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资金
- NIH [DKRO1081410]
- American Gastroenterological Association (AGA) Foundation Sucampo ASP Designated Research Award in Geriatric Gastroenterology
- Atlantic Philanthropies, Inc.
- Hartford Foundation
- Association of Specialty Professors
- AGA [K23 DK090303]
- UCSD Digestive Diseases Research Development Center [DK080506]
NAFLD is a clinical syndrome characterized by predominant macrovesicular steatosis of the liver. The clinical and histological phenotypes of NAFLD extend from a nonalcoholic fatty liver to NASH. Although the prevalence of NAFLD is increasing globally, and it is set to become the predominant cause of chronic liver disease in many parts of the world, the epidemiology and demographic characteristics of NAFLD vary worldwide. Indeed, the condition is associated with obesity and insulin resistance in most cases in the Western world, but the disease manifests at a lower BMI in Asian countries and many patients do not seem to have insulin resistance as determined using conventional methods. The similarities and differences in the epidemiology of NAFLD in different regions of the world are discussed and the potential role of genetics and insulin resistance in disease progression is also presented.
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