DIABETES Treating diabetic nephropathy-still an unresolved issue

Whether treatment of hyperglycaemia prevents progression of diabetic nephropathy is controversial. Intensive glycaemic control reduces the risk of microalbuminuria and macroalbuminuria, but there is no clear-cut evidence showing that it reduces doubling of serum creatinine levels or risk of death from kidney disease. Larger studies or further follow-up of previous trials are required to better assess renal outcomes.