期刊
NATURE REVIEWS ENDOCRINOLOGY
卷 6, 期 2, 页码 102-109出版社
NATURE PORTFOLIO
DOI: 10.1038/nrendo.2009.268
关键词
-
资金
- NIDDK NIH HHS [R01 DK052852-13, R56 DK069982, R01 DK069982, R01 DK069982-04, R56 DK052852, R01 DK052852] Funding Source: Medline
Several conventional methods of bariatric surgery can induce long-term remission of type 2 diabetes mellitus (T2DM); novel gastrointestinal surgical procedures are reported to have similar effects. These procedures also dramatically improve other metabolic conditions, including hyperlipidemia and hypertension, in both obese and nonobese patients. Several studies have provided evidence that these metabolic effects are not simply the results of drastic weight loss and decreased caloric intake but might be attributable, in part, to endocrine changes resulting from surgical manipulation of the gastrointestinal tract. In this Review, we provide an overview of the clinical evidence that demonstrates the effects of such interventions-termed metabolic surgery-on T2DM and discuss the implications for future research. In light of the evidence presented here, we speculate that the gastrointestinal tract might have a role in the pathophysiology of T2DM and obesity.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据