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BET bromodomain inhibition suppresses TH17-mediated pathology
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BET Protein Function Is Required for Inflammation: Brd2 Genetic Disruption and BET Inhibitor JQ1 Impair Mouse Macrophage Inflammatory Responses
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Fragment-Based Drug Discovery of 2-Thiazolidinones as Inhibitors of the Histone Reader BRD4 Bromodomain
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JOURNAL OF MEDICINAL CHEMISTRY (2013)
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Recruitment of Brd4 to the Human Papillomavirus Type 16 DNA Replication Complex Is Essential for Replication of Viral DNA
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NUCLEIC ACIDS RESEARCH (2013)
BET Inhibition Silences Expression of MYCN and BCL2 and Induces Cytotoxicity in Neuroblastoma Tumor Models
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ONCOTARGET (2013)
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GASTROENTEROLOGY (2012)
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Druggability Analysis and Structural Classification of Bromodomain Acetyl-lysine Binding Sites
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Paul Bamborough et al.
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Identification of a Chemical Probe for Bromo and Extra C-Terminal Bromodomain Inhibition through Optimization of a Fragment-Derived Hit
Paul V. Fish et al.
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MOLECULAR ONCOLOGY (2012)
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NUCLEIC ACIDS RESEARCH (2012)
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Tisha R. Joy
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Selective inhibition of CD4+ T-cell cytokine production and autoimmunity by BET protein and c-Myc inhibitors
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BRD4 is an atypical kinase that phosphorylates Serine2 of the RNA Polymerase II carboxy-terminal domain
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TRENDS IN PHARMACOLOGICAL SCIENCES (2012)
Small-molecule inhibition of BRD4 as a new potent approach to eliminate leukemic stem-and progenitor cells in acute myeloid leukemia (AML)
Harald Herrmann et al.
ONCOTARGET (2012)
Bromodomain Protein Brd4 Plays a Key Role in Merkel Cell Polyomavirus DNA Replication
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Differentiation of NUT Midline Carcinoma by Epigenomic Reprogramming
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CANCER RESEARCH (2011)
BET Bromodomain Inhibition as a Therapeutic Strategy to Target c-Myc
Jake E. Delmore et al.
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Real-Time Imaging of Histone H4K12-Specific Acetylation Determines the Modes of Action of Histone Deacetylase and Bromodomain Inhibitors
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A Small Molecule Binding to the Coactivator CREB-Binding Protein Blocks Apoptosis in Cardiomyocytes
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CHEMISTRY & BIOLOGY (2011)
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DEVELOPMENTAL BIOLOGY (2011)
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Susanne Muller et al.
EXPERT REVIEWS IN MOLECULAR MEDICINE (2011)
Rational therapeutic combinations with histone deacetylase inhibitors for the treatment of cancer
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FUTURE ONCOLOGY (2011)
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JOURNAL OF MEDICINAL CHEMISTRY (2011)
Discovery and Characterizatlion of Small Molecule Inhibitors of the BET Family Bromodomains
Chun-wa Chung et al.
JOURNAL OF MEDICINAL CHEMISTRY (2011)
Structural Basis and Specificity of Acetylated Transcription Factor GATA1 Recognition by BET Family Bromodomain Protein Brd3
Roland Gamsjaeger et al.
MOLECULAR AND CELLULAR BIOLOGY (2011)
Inactivating mutations of acetyltransferase genes in B-cell lymphoma
Laura Pasqualucci et al.
NATURE (2011)
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NATURE (2011)
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
Bromodomain protein Brd3 associates with acetylated GATA1 to promote its chromatin occupancy at erythroid target genes
Janine M. Lamonica et al.
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The molecular biology of HIV latency: breaking and restoring the Tat-dependent transcriptional circuit
Jonathan Karn
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Brd2 disruption in mice causes severe obesity without Type 2 diabetes
Fangnian Wang et al.
BIOCHEMICAL JOURNAL (2010)
Oncogenesis by sequestration of CBP/p300 in transcriptionally inactive hyperacetylated chromatin domains
Nicolas Reynoird et al.
EMBO JOURNAL (2010)
Mixed lineage leukemia: histone H3 lysine 4 methyltransferases from yeast to human
Shivani Malik et al.
FEBS JOURNAL (2010)
Demystified molecular pathology of NUT midline carcinomas
Christopher A. French
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RVX-208 A Small Molecule That Increases Apolipoprotein A-I and High-Density Lipoprotein Cholesterol In Vitro and In Vivo
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Junpeng Yan et al.
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