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Trp53R172H and KraSG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice
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CANCER CELL (2005)
A small-molecule inhibitor of isoprenylcysteine carboxyl methyltransferase with antitumor activity in cancer cells
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
An acylation cycle regulates localization and activity of palmitoylated Ras isoforms
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SCIENCE (2005)
Identification of V23RalA-Ser194 as a critical mediator for aurora-A-induced cellular motility and transformation by small pool expression screening
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JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
RaIGDS is required for tumor formation in a model of skin carcinoigenesis
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CANCER CELL (2005)
The concept of synthetic lethality in the context of anticancer therapy
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NATURE REVIEWS CANCER (2005)
Farnesylthiosalicylic acid inhibits mammalian target of rapamycin (mTOR) activity both in cells and in vitro by promoting dissociation of the mTOR-raptor complex
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MOLECULAR ENDOCRINOLOGY (2005)
Sulindac-derived Ras pathway inhibitors target the Ras-Raf interaction and downstream effectors in the Ras pathway
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ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2004)
BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis
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CANCER RESEARCH (2004)
Rational design and characterization of a Rac GTPase-specific small molecule inhibitor
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
The dark side of Ras: regulation of apoptosis
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ONCOGENE (2003)
Stable suppression of tumorigenicity by virus-mediated RNA interference
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CANCER CELL (2002)
Tiam1 mediates Ras activation of Rac by a PI(3)K-independent mechanism
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NATURE CELL BIOLOGY (2002)
Mice deficient in the Rac activator Tiam1 are resistant to Ras-induced skin tumours
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NATURE (2002)
Ras signalling on the endoplasmic reticulum and the Golgi
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NATURE CELL BIOLOGY (2002)
Cys-328 of IscS and Cys-63 of IscU are the sites of disulfide bridge formation in a covalently bound IscS/IscU complex: Implications for the mechanism of iron-sulfur cluster assembly
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)
P-Rex1, a PtdIns(3,4,5)P3- and Gβγ-regulated guanine-nucleotide exchange factor for Rac
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CELL (2002)
New indene-derivatives with anti-proliferative properties
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BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2002)
Induction and apoptotic regression of lung adenocarcinomas by regulation of a K-Ras transgene in the presence and absence of tumor suppressor genes
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GENES & DEVELOPMENT (2001)
Wildtype Kras2 can inhibit lung carcinogenesis in mice
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NATURE GENETICS (2001)
Discovery of a novel Raf kinase inhibitor
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ENDOCRINE-RELATED CANCER (2001)
Cell biology - Principles for the buffering of genetic variation
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SCIENCE (2001)
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