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Mechanisms of apoptosis sensitivity and resistance to the BH3 mimetic ABT-737 in acute myeloid leukemia
Marina Konopleva et al.
CANCER CELL (2006)
A stapled BID BH3 helix directly binds and activates BAX
Loren D. Walensky et al.
MOLECULAR CELL (2006)
iASPP preferentially binds p53 proline-rich region and modulates apoptotic function of codon 72 polymorphic p53
Daniele Bergamaschi et al.
NATURE GENETICS (2006)
The pathological response to DNA damage does not contribute to p53-mediated tumour suppression
M. A. Christophorou et al.
NATURE (2006)
Policing of oncogene activity by p53
Alejo Efeyan et al.
NATURE (2006)
(R)-roscovitine (CYC202, Seliciclib) sensitizes SH-SY5Y neuroblastorna cells to nutlin-3-induced apoptosis
Judit Ribas et al.
EXPERIMENTAL CELL RESEARCH (2006)
Functional integrity of the p53-mediated apoptotic pathway induced by the nongenotoxic agent nutlin-3 in B-cell chronic lymphocytic leukemia (B-CLL)
Paola Secchiero et al.
BLOOD (2006)
MDM2 antagonists activate p53 and synergize with genotoxic drugs in B-cell chronic lymphocytic leukemia cells
Llorenc Coll-Mulet et al.
BLOOD (2006)
Tumor suppression by p53 without accelerated aging - Just enough of a good thing?
Susan M. Mendrysa et al.
CELL CYCLE (2006)
An shRNA barcode screen provides insight into cancer cell vulnerability to MDM2 inhibitors
TR Brummelkamp et al.
NATURE CHEMICAL BIOLOGY (2006)
Levels of HdmX expression dictate the sensitivity of normal and transformed cells to nutlin-3
JT Patton et al.
CANCER RESEARCH (2006)
Small-molecule MDM2 antagonists reveal aberrant p53 signaling in cancer: Implications for therapy
C Tovar et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Radiosensitization of lung cancer by nutlin, an inhibitor of murine double minute 2
C Cao et al.
MOLECULAR CANCER THERAPEUTICS (2006)
Benzodiazepinedione inhibitors of the Hdm2 : p53 complex suppress human tumor cell proliferation in vitro and sensitize tumors to doxorubicin in vivo
HK Koblish et al.
MOLECULAR CANCER THERAPEUTICS (2006)
The antioxidant function of the p53 tumor suppressor
AA Sablina et al.
NATURE MEDICINE (2005)
Gaucher disease-associated glucocerebrosidases show mutation-dependent chemical chaperoning profiles
AR Sawkar et al.
CHEMISTRY & BIOLOGY (2005)
Seliciclib (CYC202, R-roscovitine) induces cell death in multiple myeloma cells by inhibition of RNA polymerase II-dependent transcription and down-regulation of Mcl-1
DE MacCallum et al.
CANCER RESEARCH (2005)
Activation of p53 by MDM2 antagonists can protect proliferating cells from mitotic inhibitors
D Carvajal et al.
CANCER RESEARCH (2005)
Discovery and cocrystal structure of benzodiazepinedione HDM2 antagonists that activate p53 in cells
BL Grasberger et al.
JOURNAL OF MEDICINAL CHEMISTRY (2005)
Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function
L Chen et al.
MOLECULAR CELL (2005)
The expression of iASPP in acute leukemias
XW Zhang et al.
LEUKEMIA RESEARCH (2005)
Chalcones: An update on cytotoxic and chemoprotective properties
ML Go et al.
CURRENT MEDICINAL CHEMISTRY (2005)
Terphenyl-based helical mimetics that disrupt the p53/HDM2 interaction
H Yin et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2005)
Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis
JE Chipuk et al.
SCIENCE (2004)
In vivo activation of the p53 pathway by small-molecule antagonists of MDM2
LT Vassilev et al.
SCIENCE (2004)
Activation of apoptosis in vivo by a hydrocarbon-stapled BH3 helix
LD Walensky et al.
SCIENCE (2004)
A nonpeptidic sulfonamide inhibits the p53-mdm2 interaction and activates p53-dependent transcription in mdm2-overexpressing cells
PS Galatin et al.
JOURNAL OF MEDICINAL CHEMISTRY (2004)
Small molecule RITA binds to p53, blocks p53-HDM-2 interaction and activates p53 function in tumors
N Issaeva et al.
NATURE MEDICINE (2004)
A single nucleotide polymorphism in the MDM2 promoter attenuates the p53 tumor suppressor pathway and accelerates tumor formation in humans
GL Bond et al.
CELL (2004)
TNF-related apoptosis-inducing ligand (TRAIL): A potential candidate for combined treatment of hematological malignancies
P Secchiero et al.
CURRENT PHARMACEUTICAL DESIGN (2004)
p53- and drug-induced apoptotic responses mediated by BH3-only proteins Puma and Noxa
A Villunger et al.
SCIENCE (2003)
p53 has a direct apoptogenic role at the mitochondria
M Mihara et al.
MOLECULAR CELL (2003)
mdm2 is critical for inhibition of p53 during lymphopoiesis and the response to ionizing irradiation
SM Mendrysa et al.
MOLECULAR AND CELLULAR BIOLOGY (2003)
Acetylation of p53 inhibits its ubiquitination by Mdm2
MY Li et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Chemical chaperones increase the cellular activity of N370S β-glucosidase:: A therapeutic strategy for Gaucher disease
AR Sawkar et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)
'Super p53' mice exhibit enhanced DNA damage response, are tumor resistant and age normally
I García-Cao et al.
EMBO JOURNAL (2002)
Stromal cells prevent apoptosis of AML cells by up-regulation of anti-apoptotic proteins
M Konopleva et al.
LEUKEMIA (2002)
Regulation of p53 activity by its interaction with homeodomain-interacting protein kinase-2
TG Hofmann et al.
NATURE CELL BIOLOGY (2002)
Homeodomain-interacting protein kinase-2 phosphorylates p53 at Ser 46 and mediates apoptosis
G D'Orazi et al.
NATURE CELL BIOLOGY (2002)
Restoration of the tumor suppressor function to mutant p53 by a low-molecular-weight compound
VJN Bykov et al.
NATURE MEDICINE (2002)
ASPP proteins specifically stimulate the apoptotic function of p53
Y Samuels-Lev et al.
MOLECULAR CELL (2001)
Toward proteomimetics:: Terphenyl derivatives as structural and functional mimics of extended regions of an α-helix
BP Orner et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2001)
Chalcone derivatives antagonize interactions between the human oncoprotein MDM2 and p53
R Stoll et al.
BIOCHEMISTRY (2001)
p53AlP1, a potential mediator of p53-dependent apoptosis, and its regulation by Ser-46-phosphorylated p53
K Oda et al.
CELL (2000)
An all-hydrocarbon cross-linking system for enhancing the helicity and metabolic stability of peptides
CE Schafmeister et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2000)
A small synthetic peptide, which inhibits the p53-hdm2 interaction, stimulates the p53 pathway in tumour cell lines
P Chène et al.
JOURNAL OF MOLECULAR BIOLOGY (2000)
Damage-mediated phosphorylation of human p53 threonine 18 through a cascade mediated by a casein 1-like kinase - Effect on Mdm2 binding
K Sakaguchi et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
Mechanism of rescue of common p53 cancer mutations by second-site suppressor mutations
PV Nikolova et al.
EMBO JOURNAL (2000)