期刊
NATURE REVIEWS DRUG DISCOVERY
卷 13, 期 2, 页码 123-139出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nrd4189
关键词
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资金
- Netherlands Organization for Scientific Research (NWO)
- Dutch Technology Foundation (STW)
Herpesviruses encode membrane-associated G protein-coupled receptors (GPCRs) in their viral genomes that are structurally similar to chemokine receptors. These GPCRs hijack GPCR-mediated cellular signalling networks of the host for survival, replication and pathogenesis. In particular the herpesvirus-encoded chemokine receptors ORF74, BILF1 and US28, which are present at inflammatory sites and tumour cells, provide important virus-specific targets for directed therapies. Given the high druggability of GPCRs in general, these viral GPCRs can be considered promising antiviral drug targets.
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