期刊
NATURE REVIEWS DRUG DISCOVERY
卷 12, 期 5, 页码 348-358出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nrd3978
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资金
- Swedish Society of Medical Research (SSMF)
- Swedish Medical Research Council (VR-med unga forskare)
- Estonian Science Foundation
- Medical Research Council [G0900887] Funding Source: researchfish
- Parkinson's UK [G-1109] Funding Source: researchfish
- MRC [G0900887] Funding Source: UKRI
Within the past decade, extracellular vesicles have emerged as important mediators of intercellular communication, being involved in the transmission of biological signals between cells in both prokaryotes and higher eukaryotes to regulate a diverse range of biological processes. In addition, pathophysiological roles for extracellular vesicles are beginning to be recognized in diseases including cancer, infectious diseases and neurodegenerative disorders, highlighting potential novel targets for therapeutic intervention. Moreover, both unmodified and engineered extracellular vesicles are likely to have applications in macro-molecular drug delivery. Here, we review recent progress in understanding extracellular vesicle biology and the role of extracellular vesicles in disease, discuss emerging therapeutic opportunities and consider the associated challenges.
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