期刊
NATURE REVIEWS DRUG DISCOVERY
卷 12, 期 9, 页码 688-702出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nrd4099
关键词
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资金
- US National Institutes of Health (NIH) [R37GM043880, RO1CA61774]
- NIH [T32 HL094290]
The bioactive lipid sphingosine-1-phosphate (S1P) is involved in multiple cellular signalling systems and has a pivotal role in the control of immune cell trafficking. As such, S1P has been implicated in disorders such as cancer and inflammatory diseases. This Review discusses the ways in which S1P might be therapeutically targeted - for example, via the development of chemical inhibitors that target the generation, transport and degradation of S1P and via the development of specific S1P receptor agonists. We also highlight recent conflicting results observed in preclinical studies targeting S1P and discuss ongoing clinical trials in this field.
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