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Andres M. Kanner
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Samuel Wiebe et al.
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Evidence-based guideline update: Medical treatment of infantile spasms Report of the Guideline Development Subcommittee of the American Academy of Neurology and the Practice Committee of the Child Neurology Society
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Progress on the issue of excitotoxic injury modification vs. real neuroprotection; implications for post-traumatic epilepsy
Robert S. Sloviter
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Jeffrey A. Loeb
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Combining antiepileptic drugs-Rational polytherapy?
Martin J. Brodie et al.
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Critical review of current animal models of seizures and epilepsy used in the discovery and development of new antiepileptic drugs
Wolfgang Loescher
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Leveraging Biomarker Platforms and Systems Biology for Rehabilomics and Biologics Effectiveness Research
Firas H. Kobeissy et al.
PM&R (2011)
Treatment of refractory epilepsy with natalizumab in a patient with multiple sclerosis. Case report
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BMC NEUROLOGY (2010)
Imaging of P-glycoprotein Function and Expression to Elucidate Mechanisms of Pharmacoresistance in Epilepsy
Wolfgang Loescher et al.
CURRENT TOPICS IN MEDICINAL CHEMISTRY (2010)
Comparison of the antiepileptogenic effects of an early long-term treatment with ethosuximide or levetiracetam in a genetic animal model of absence epilepsy
Emilio Russo et al.
EPILEPSIA (2010)
Definition of drug resistant epilepsy: Consensus proposal by the ad hoc Task Force of the ILAE Commission on Therapeutic Strategies
Patrick Kwan et al.
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Placebo-corrected efficacy of modern antiepileptic drugs for refractory epilepsy: Systematic review and meta-analysis
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Revised terminology and concepts for organization of seizures and epilepsies: Report of the ILAE Commission on Classification and Terminology, 2005-2009
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A comparison of pregabalin, lamotrigine, and placebo as adjunctive therapy in patients with refractory partial-onset seizures
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Progress report on new antiepileptic drugs: A summary of the Tenth Eilat Conference (EILAT X)
Meir Bialer et al.
EPILEPSY RESEARCH (2010)
Increased Risk of Death Among Children With Lennox-Gastaut Syndrome and Infantile Spasms
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Disease-Modifying Effects of Phenobarbital and the NKCC1 Inhibitor Bumetanide in the Pilocarpine Model of Temporal Lobe Epilepsy
Claudia Brandt et al.
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Toll-like receptor 4 and high-mobility group box-1 are involved in ictogenesis and can be targeted to reduce seizures
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Blood-brain barrier breakdown as a therapeutic target in traumatic brain injury
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Wolfgang Loescher et al.
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Benefit of combination therapy in epilepsy: A review of the preclinical evidence with levetiracetam
Rafal M. Kaminski et al.
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High-frequency oscillations: What is normal and what is not?
Jerome Engel et al.
EPILEPSIA (2009)
Preventing and treating posttraumatic seizures: The human experience
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EPILEPSIA (2009)
Drug treatment of epilepsy: Options and limitations
Dieter Schmidt
EPILEPSY & BEHAVIOR (2009)
Blood-brain barrier breakdown-inducing astrocytic transformation: Novel targets for the prevention of epilepsy
Alon Friedman et al.
EPILEPSY RESEARCH (2009)
Pharmacodynamic interactions between antiepileptic drugs: preclinical data based on isobolography
Stanislaw J. Czuczwar et al.
EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY (2009)
Transcriptome Profiling Reveals TGF-β Signaling Involvement in Epileptogenesis
Luisa P. Cacheaux et al.
JOURNAL OF NEUROSCIENCE (2009)
Lessons from 60 years of pharmaceutical innovation
Bernard Munos
NATURE REVIEWS DRUG DISCOVERY (2009)
NEW DEVELOPMENTS IN ANTIEPILEPTIC DRUG RESISTANCE: AN INTEGRATIVE VIEW
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EPILEPSY CURRENTS (2009)
Rapamycin prevents epilepsy in a mouse model of tuberous sclerosis complex
Ling-Hui Zeng et al.
ANNALS OF NEUROLOGY (2008)
The role of cytokines in the pathophysiology of epilepsy
Annamaria Vezzani et al.
BRAIN BEHAVIOR AND IMMUNITY (2008)
The state of innovation in drug development
I. Kola
CLINICAL PHARMACOLOGY & THERAPEUTICS (2008)
Early treatment suppresses the development of spike-wave epilepsy in a rat model
Hal Blumenfeld et al.
EPILEPSIA (2008)
Reduction of secondarily generalized tonic-clonic (SGTC) seizures with pregabalin
Deborah E. Briggs et al.
EPILEPSY RESEARCH (2008)
Network pharmacology: the next paradigm in drug discovery
Andrew L. Hopkins
NATURE CHEMICAL BIOLOGY (2008)
A role for leukocyte-endothelial adhesion mechanisms in epilepsy
Paolo F. Fabene et al.
NATURE MEDICINE (2008)
Quantifying the response to antiepileptic drugs
Yitzhak Schiller et al.
NEUROLOGY (2008)
Levetiracetam: the first SV2A ligand for the treatment of epilepsy
Henrik Klitgaard et al.
EXPERT OPINION ON DRUG DISCOVERY (2007)
The SANAD study of effectiveness of carbamazepine, gabapentin, lamotrigine, oxcarbazepine, or topiramate for treatment of partial epilepsy: an unblinded randomised controlled trial
Anthony G. Marson et al.
LANCET (2007)
The SANAD study of effectiveness of valproate, lamotrigine, or topiramate for generalised and unclassifiable epilepsy: an unblinded randomised controlled trial
Anthony G. Marson et al.
LANCET (2007)
Development of new antiepileptic drugs: challenges, incentives, and recent advances
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LANCET NEUROLOGY (2007)
The multidrug transporter hypothesis of drug resistance in epilepsy:: Proof-of-principle in a rat model of temporal lobe epilepsy
Claudia Brandt et al.
NEUROBIOLOGY OF DISEASE (2006)
Neuronal sensitivity to kainic acid is dependent on the Nrf2-mediated actions of the antioxidant response element
Andrew D. Kraft et al.
JOURNAL OF NEUROCHEMISTRY (2006)
Natural history of treated childhood-onset epilepsy:: prospective, long-term population-based study
M Sillanpää et al.
BRAIN (2006)
Clinical trials for prevention of epileptogenesis
ST Herman
EPILEPSY RESEARCH (2006)
Molecular and cellular mechanisms of pharmacoresistance in epilepsy
S Remy et al.
BRAIN (2006)
NKCC1 transporter facilitates seizures in the developing brain
VI Dzhala et al.
NATURE MEDICINE (2005)
An integrative genomics approach to infer causal associations between gene expression and disease
EE Schadt et al.
NATURE GENETICS (2005)
Drug resistance in epilepsy:: Putative neurobiologic and clinical mechanisms
D Schmidt et al.
EPILEPSIA (2005)
Multiple facets of GABAergic neurons and synapses: multiple fates of GABA signalling in epilepsies
R Cossart et al.
TRENDS IN NEUROSCIENCES (2005)
Adverse effects of antiepileptic drugs
E Perucca et al.
ACTA NEUROLOGICA SCANDINAVICA (2005)
Dysregulation of the TSC-mTOR pathway in human disease
K Inoki et al.
NATURE GENETICS (2005)
Striking differences in individual anticonvulsant response to phenobarbital in rats with spontaneous seizures after status epilepticus
C Brandt et al.
EPILEPSIA (2004)
The neurobiology of antiepileptic drugs for the treatment of nonepileptic conditions
MA Rogawski et al.
NATURE MEDICINE (2004)
The neurobiology of antiepileptic drugs
MA Rogawski et al.
NATURE REVIEWS NEUROSCIENCE (2004)
Topiramate, carbamazepine and valproate monotherapy: double-blind comparison in newly diagnosed epilepsy
MD Privitera et al.
ACTA NEUROLOGICA SCANDINAVICA (2003)
On the origin of interictal activity in human temporal lobe epilepsy in vitro
I Cohen et al.
SCIENCE (2002)
Do preclinical seizure models preselect certain adverse effects of antiepileptic drugs
B Meldrum
EPILEPSY RESEARCH (2002)
Use of epileptic animals for adverse effect testing
H Klitgaard et al.
EPILEPSY RESEARCH (2002)
Functional role of inflammatory cytokines and antiinflammatory molecules in seizures and epileptogenesis
A Vezzani et al.
EPILEPSIA (2002)
Pharmacological characterization of the 6 Hz psychomotor seizure model of partial epilepsy
ME Barton et al.
EPILEPSY RESEARCH (2001)
Powerful anticonvulsant action of IL-1 receptor antagonist on intracerebral injection and astrocytic overexpression in mice
A Vezzani et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)