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Autophagy modulation as a potential therapeutic target for diverse diseases

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NATURE REVIEWS DRUG DISCOVERY
卷 11, 期 9, 页码 709-U84

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NATURE PORTFOLIO
DOI: 10.1038/nrd3802

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资金

  1. Wellcome Trust
  2. Wellcome Trust/Medical Research Council
  3. UK Medical Research Council
  4. National Institute for Health Research Biomedical Research Unit in Dementia at Addenbrooke's Hospital, Cambridge, UK
  5. US National Institutes of Health (NIH) [RO1 CA109618, U54AI057156]
  6. INSERM
  7. Universite Paris-Sud
  8. Agence Nationale pour la Recherche
  9. Institut National du Cancer
  10. MRC [G0600194, MC_G1000734] Funding Source: UKRI
  11. Medical Research Council [G0600194, MC_G1000734] Funding Source: researchfish

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Autophagy is an essential, conserved lysosomal degradation pathway that controls the quality of the cytoplasm by eliminating protein aggregates and damaged organelles. It begins when double-membraned autophagosomes engulf portions of the cytoplasm, which is followed by fusion of these vesicles with lysosomes and degradation of the autophagic contents. In addition to its vital homeostatic role, this degradation pathway is involved in various human disorders, including metabolic conditions, neurodegenerative diseases, cancers and infectious diseases. This article provides an overview of the mechanisms and regulation of autophagy, the role of this pathway in disease and strategies for therapeutic modulation.

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