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Darlene E. Berryman et al.
GROWTH HORMONE & IGF RESEARCH (2008)
SIRT1 modulation of the acetylation status, cytosolic localization, and activity of LKB1 - Possible role in AMP-activated protein kinase activation
Fan Lan et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
SIRT1 regulates hepatocyte lipid metabolism through activating AMP-activated protein kinase
Xiuyun Hou et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Interplay among BRCA1, SIRT1, and Survivin during BRCA1-Associated Tumorigenesis
Rui-Hong Wang et al.
MOLECULAR CELL (2008)
Caffeine extends yeast lifespan by targeting TORC1
Valeria Wanke et al.
MOLECULAR MICROBIOLOGY (2008)
SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin
Eriko Michishita et al.
NATURE (2008)
SirT1 Regulates Energy Metabolism and Response to Caloric Restriction in Mice
Gino Boily et al.
PLOS ONE (2008)
The SIRT1 Deacetylase Suppresses Intestinal Tumorigenesis and Colon Cancer Growth
Ron Firestein et al.
PLOS ONE (2008)
A Low Dose of Dietary Resveratrol Partially Mimics Caloric Restriction and Retards Aging Parameters in Mice
Jamie L. Barger et al.
PLOS ONE (2008)
Sirt1 protects against high-fat diet-induced metabolic damage
Paul T. Pfluger et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Mammalian sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation
David B. Lombard et al.
MOLECULAR AND CELLULAR BIOLOGY (2007)
SIRT1 transgenic mice show phenotypes resembling calorie restriction
Laura Bordone et al.
AGING CELL (2007)
Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes
Jill C. Milne et al.
NATURE (2007)
SIRT1 regulates the histone methyl-transferase SUV39H1 during heterochromatin formation
Alejandro Vaquero et al.
NATURE (2007)
Long-term follow-up of the West of Scotland Coronary Prevention Study
Ian Ford et al.
NEW ENGLAND JOURNAL OF MEDICINE (2007)
Effects of resveratrol on lifespan in Drosophila melanogaster and Caenorhabditis elegans
Timothy M. Bass et al.
MECHANISMS OF AGEING AND DEVELOPMENT (2007)
SIRT1 promotes endothelium-dependent vascular relaxation by activating endothelial nitric oxide synthase
Ilwola Mattagajasingh et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Mechanism of inhibition of bovine F1-ATPase by resveratrol and related polyphenols
Jonathan R. Gledhill et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
An aging Interventions Testing Program: study design and interim report
Richard A. Miller et al.
AGING CELL (2007)
Fasting-dependent glucose and lipid metabolic response through hepatic sirtuin 1
Joseph T. Rodgers et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Sirtuin 2 inhibitors rescue α-synuclein-mediated toxicity in models of Parkinson's disease
Tiago Fleming Outeiro et al.
SCIENCE (2007)
AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1α
Sibylle Jaeger et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis
Dohoon Kim et al.
EMBO JOURNAL (2007)
Sirt1 regulates aging and resistance to oxidative stress in the heart
Ralph R. Alcendor et al.
CIRCULATION RESEARCH (2007)
Resveratrol increases vascular oxidative stress resistance
Zoltan Ungvari et al.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2007)
Resveratrol stimulates AMP kinase activity in neurons
Biplab Dasgupta et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Resveratrol attenuates oxLDL-stimulated NADPH oxidase activity and protects endothelial cells from oxidative functional damages
Shu-Er Chow et al.
JOURNAL OF APPLIED PHYSIOLOGY (2007)
Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1α
Marie Lagouge et al.
CELL (2006)
Resveratrol improves health and survival of mice on a high-calorie diet
Joseph A. Baur et al.
NATURE (2006)
SIRT4 inhibits glutamate dehydrogehase and opposes the effects of calorie restriction in pancreatic β cells
Marcia C. Haigis et al.
CELL (2006)
Resveratrol inhibits aggregation of platelets from high-risk cardiac patients with aspirin resistance
Gyorgyi Stef et al.
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY (2006)
Regulation of proliferation and gene expression in cultured human aortic smooth muscle cells by resveratrol and standardized grape extracts
Zhirong Wang et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2006)
Neuroprotective effects of resveratrol on cerebral ischemia-induced neuron loss mediated by free radical scavenging and cerebral blood flow elevation
KT Lu et al.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2006)
Calorie restriction mimetics: an emerging research field
DK Ingram et al.
AGING CELL (2006)
Resveratrol prolongs lifespan and retards the onset of age-related markers in a short-lived vertebrate
DR Valenzano et al.
CURRENT BIOLOGY (2006)
Genomic instability and aging-like phenotype in the absence of mammalian SIRT6
R Mostoslavsky et al.
CELL (2006)
Altered mitochondrial energy metabolism may play a role in vascular aging
Anna Csiszar et al.
MEDICAL HYPOTHESES (2006)
Can dietary restriction increase longevity in all species, particularly in human beings? Introduction to a debate among experts
ric Le Bourg et al.
BIOGERONTOLOGY (2006)
Overlapping and distinct functions for a Caenorhabditis elegans SIR2 and DAF-16/FOXO
YM Wang et al.
MECHANISMS OF AGEING AND DEVELOPMENT (2006)
Therapeutic potential of resveratrol: the in vivo evidence
Joseph A. Baur et al.
NATURE REVIEWS DRUG DISCOVERY (2006)
Increase in activity during calorie restriction requires Sirt1
D Chen et al.
SCIENCE (2005)
Age-related changes in the hepatic sinusoidal endothelium impede lipoprotein transfer in the rat
SN Hilmer et al.
HEPATOLOGY (2005)
Effects of physical activity on life expectancy with cardiovascular disease
OH Franco et al.
ARCHIVES OF INTERNAL MEDICINE (2005)
Evolutionarily conserved and nonconserved cellular localizations and functions of human SIRT proteins
E Michishita et al.
MOLECULAR BIOLOGY OF THE CELL (2005)
Resveratrol suppresses interferon-γ-induced biochemical pathways in human peripheral blood mononuclear cells in vitro
B Wirleitner et al.
IMMUNOLOGY LETTERS (2005)
Increased dosage of mammalian Sir2 in pancreatic β cells enhances glucose-stimulated insulin secretion in mice
KA Moynihan et al.
CELL METABOLISM (2005)
Mouse Sir2 homolog SIRT6 is a nuclear ADP-ribosyltransferase
G Liszt et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Mechanism of human SIRT1 activation by resveratrol
MT Borra et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Substrate-specific activation of sirtuins by resveratrol
M Kaeberlein et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
SIRT1 functionally interacts with the metabolic regulator and transcriptional coactivator PGC-1α
S Nemoto et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
SIRT3, a mitochondrial sirtuin deacetylase, regulates mitochondrial function and thermogenesis in brown adipocytes
T Shi et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Resveratrol rescues mutant polyglutamine cytotoxicity in nematode and mammalian neurons
JA Parker et al.
NATURE GENETICS (2005)
Nutrient control of glucose homeostasis through a complex of PGC-1α and SIRT1
JT Rodgers et al.
NATURE (2005)
A novel VNTR enhancer within the SIRT3 gene, a human homologue of SIR2, is associated with survival at oldest ages
D Bellizzi et al.
GENOMICS (2005)
The unfortunate influence of the weather on the rate of ageing: Why human caloric restriction or its emulation may only extend life expectancy by 2-3 years
ADNJ de Grey
GERONTOLOGY (2005)
Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase
A Brunet et al.
SCIENCE (2004)
Mammalian SIRT1 represses forkhead transcription factors
MC Motta et al.
CELL (2004)
Resveratrol inhibits phenotypic and functional maturation of murine bone marrow-derived dendritic cells
GY Kim et al.
INTERNATIONAL IMMUNOPHARMACOLOGY (2004)
Sir2-independent life span extension by calorie restriction in yeast
M Kaeberlein et al.
PLOS BIOLOGY (2004)
Effect of trans-resveratrol on the thrombogenicity and atherogenicity in apolipoprotein E-deficient and low-density lipoprotein receptor-deficient mice
H Fukao et al.
BLOOD COAGULATION & FIBRINOLYSIS (2004)
An accelerated assay for the identification of lifespan-extending interventions in Drosophila melanogaster
JH Bauer et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
Increased nuclear NAD biosynthesis and SIRT1 activation prevent axonal degeneration
T Araki et al.
SCIENCE (2004)
Sirtuin activators mimic caloric restriction and delay ageing in metazoans
JG Wood et al.
NATURE (2004)
Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase
HY Cohen et al.
SCIENCE (2004)
FOXO4 is acetylated upon peroxide stress and deacetylated by the longevity protein hSir2SIRT1
A van der Horst et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Silent information regulator 2α, a longevity factor and class III histone deacetylase, is an essential endogenous apoptosis inhibitor in cardiac myocytes
RR Alcendor et al.
CIRCULATION RESEARCH (2004)
Mortality in relation to smoking: 50 years' observations on male British doctors
R Doll et al.
BMJ-BRITISH MEDICAL JOURNAL (2004)
Sir2 mediates longevity in the fly through a pathway related to calorie restriction
B Rogina et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-γ
F Picard et al.
NATURE (2004)
Modulation of NF-κB-dependent transcription and cell survival by the SIRT1 deacetylase
F Yeung et al.
EMBO JOURNAL (2004)
A novel assay for replicative lifespan in Saccharomyces cerevisiae
S Jarolim et al.
FEMS YEAST RESEARCH (2004)
Brain protection by resveratrol and fenofibrate against stroke requires peroxisome proliferator-activated receptor α in mice
H Inoue et al.
NEUROSCIENCE LETTERS (2003)
Variability of the SIRT3 gene, human silent information regulator Sir2 homologue, and survivorship in the elderly
G Rose et al.
EXPERIMENTAL GERONTOLOGY (2003)
Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice
HL Cheng et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan
KT Howitz et al.
NATURE (2003)
Resveratrol, a red wine constituent polyphenol, prevents superoxide-dependent inflammatory responses induced by ischemia/reperfusion, platelet-activating factor, or oxidants
S Shigematsu et al.
FREE RADICAL BIOLOGY AND MEDICINE (2003)
Upregulation and activation of eNOS by resveratrol
D Taubert et al.
CIRCULATION (2003)
The human Sir2 ortholog, SIRT2, is an NAD+-dependent tubulin deacetylase
BJ North et al.
MOLECULAR CELL (2003)
The mammalian SIR2 alpha protein has a role in embryogenesis and gametogenesis
MW McBurney et al.
MOLECULAR AND CELLULAR BIOLOGY (2003)
Resveratrol, a polyphenolic phytoalexin present in red wine, enhances expression and activity of endothelial nitric oxide synthase
T Wallerath et al.
CIRCULATION (2002)
Benefits of smoking cessation for longevity
DH Taylor et al.
AMERICAN JOURNAL OF PUBLIC HEALTH (2002)
Immunomodulatory activity of resveratrol: suppression of lymphocyte proliferation, development of cell-mediated cytotoxicity, and cytokine production
XH Gao et al.
BIOCHEMICAL PHARMACOLOGY (2001)
The effect of low-dose daily aspirin intake on survival in the Finnish Centenarians cohort
H Agüero-Torres et al.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY (2001)
Negative control of p53 by Sir2α promotes cell survival under stress
JY Luo et al.
CELL (2001)
hSIR2SIRT1 functions as an NAD-dependent p53 deacetylase
H Vaziri et al.
CELL (2001)
Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans
HA Tissenbaum et al.
NATURE (2001)
Frailty in older adults: Evidence for a phenotype
LP Fried et al.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES (2001)
Effect of resveratrol on intimal hyperplasia after endothelial denudation in an experimental rabbit model
JG Zou et al.
LIFE SCIENCES (2000)
Resveratrol acts as a mixed agonist/antagonist for estrogen receptors α and β
JL Bowers et al.
ENDOCRINOLOGY (2000)
Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae
SJ Lin et al.
SCIENCE (2000)
A phylogenetically conserved NAD+-dependent protein deacetylase activity in the Sir2 protein family
JS Smith et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)
Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase
S Imai et al.
NATURE (2000)
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