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Gut-expressed gustducin and taste receptors regulate secretion of glucagon-like peptide-1
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
T1R3 and gustducin in gut sense sugars to regulate expression of Na+-glucose cotransporter 1
Robert F. Margolskee et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Agonist lead identification for the high affinity niacin receptor GPR109a
Tawfik Gharbaoui et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2007)
Extended-release niacin raises adiponectin and leptin
Sabine Westphal et al.
ATHEROSCLEROSIS (2007)
Expression of free fatty acid receptor GPR40 in the central nervous system of adult monkeys
Dexuan Ma et al.
NEUROSCIENCE RESEARCH (2007)
Nicotinic acid receptor agonists differentially activate downstream effectors
Jeremy G. Richman et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Synthesis and biological evaluation of 3-aryl-3-(4-phenoxy)-propionic acid as a novel series of g protein-coupled receptor 40 agonists
Fengbin Song et al.
JOURNAL OF MEDICINAL CHEMISTRY (2007)
G protein-coupled receptor 84, a microglia-associated protein expressed in neuroinflammatory conditions
Caroline Bouchard et al.
GLIA (2007)
Nicotinic acid receptor subtypes and their ligands
Willem Soudijn et al.
MEDICINAL RESEARCH REVIEWS (2007)
Seven transmembrane receptors: something old, something new
R. J. Lefkowitz
ACTA PHYSIOLOGICA (2007)
Critical role of cholesterol ester transfer protein in nicotinic acid-mediated HDL elevation in mice
Melba Hernandez et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2007)
Analogues of Acifran: Agonists of the high and low affinity niacin receptors, GPR109a and GPR109b
Jae-Kyu Jung et al.
JOURNAL OF MEDICINAL CHEMISTRY (2007)
GPR40 is necessary but not sufficient for fatty acid stimulation of insulin secretion in vivo
Martin G. Latour et al.
DIABETES (2007)
The regulation of adipogenesis through GPR120
Chizu Gotoh et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2007)
Lactate release from adipose tissue and skeletal muscle in vivo: defective insulin regulation in insulin-resistant obese women
Veronica Qvisth et al.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2007)
Taste-signaling proteins are coexpressed in solitary intestinal epithelial cells
Carole Bezencon et al.
CHEMICAL SENSES (2007)
Uncovering the pharmacology of the G protein-coupled receptor GPR40: High apparent constitutive activity in guanosine 5'-O-(3-[S-35] thio) triphosphate binding studies reflects binding of an endogenous agonist
Leigh A. Stoddart et al.
MOLECULAR PHARMACOLOGY (2007)
Nicotinic acid-induced flushing is mediated by activation of epidermal langerhans cells
Zoltan Benyo et al.
MOLECULAR PHARMACOLOGY (2006)
Langerhans cells release prostaglandin D2 in response to nicotinic acid
Dominique Maciejewski-Lenoir et al.
JOURNAL OF INVESTIGATIVE DERMATOLOGY (2006)
Medium-chain fatty acids as ligands for orphan G protein-coupled receptor GPR84
Jinghong Wang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Fumaric acid esters are effective in chronic experimental autoimmune encephalomyelitis and suppress macrophage infiltration
S. Schilling et al.
CLINICAL AND EXPERIMENTAL IMMUNOLOGY (2006)
The nicotinic acid receptor GPR109A (HM74A or PUMA-G) as a new therapeutic target
Stefan Offermanns
TRENDS IN PHARMACOLOGICAL SCIENCES (2006)
Pharmacological regulation of insulin secretion in MIN6 cells through the fatty acid receptor GPR40: identification of agonist and antagonist small molecules
Celia P. Briscoe et al.
BRITISH JOURNAL OF PHARMACOLOGY (2006)
Enhancement of arachidonic acid signaling pathway by nicotinic acid receptor HM74A
YT Tang et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2006)
Expression of the gene for a membrane-bound fatty acid receptor in the pancreas and islet cell tumours in humans: evidence for GPR40 expression in pancreatic beta cells and implications for insulin secretion
T Tomita et al.
DIABETOLOGIA (2006)
Antagonism of the prostaglandin D2 receptor 1 suppresses nicotinic acid-induced vasodilation in mice and humans
K Cheng et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Synthesis and activity of small molecule GPR40 agonists
DM Garrido et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2006)
Antiatherogenic small, dense HDL - guardian angel of the arterial wall?
A Kontush et al.
NATURE CLINICAL PRACTICE CARDIOVASCULAR MEDICINE (2006)
1-Alkyl-benzotriazole-5-carboxylic acids are highly selective agonists of the human orphan G-protein-coupled receptor GPR109b
G Semple et al.
JOURNAL OF MEDICINAL CHEMISTRY (2006)
Triglyceride modulation by acifran analogs: activity towards the niacin high and low affinity G protein-coupled receptors HM74A and HM74
K Mahboubi et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2006)
Short-chain fatty acid receptor, GPR43, is expressed by enteroendocrine cells and mucosal mast cells in rat intestine
S Karaki et al.
CELL AND TISSUE RESEARCH (2006)
GPR109A (PUMA-G/HM74A) mediates nicotinic acid-induced flushing
Z Benyó et al.
JOURNAL OF CLINICAL INVESTIGATION (2005)
Acetate and propionate short chain fatty acids stimulate adipogenesis via GPCR43
YH Hong et al.
ENDOCRINOLOGY (2005)
The G-protein coupled receptor, GPR84 regulates IL-4 production by T lymphocytes in response to CD3 crosslinking
C Venkataraman et al.
IMMUNOLOGY LETTERS (2005)
Distinct contributions of T1R2 and T1R3 taste receptor subunits to the detection of sweet stimuli
Y Nie et al.
CURRENT BIOLOGY (2005)
Characterization of determinants of ligand binding to the nicotinic acid receptor GPR109A (HM74A/PUMA-G)
S Tunaru et al.
MOLECULAR PHARMACOLOGY (2005)
Identification of the cyclamate interaction site within the transmembrane domain of the human sweet taste receptor subunit T1R3
PH Jiang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Mammalian G proteins and their cell type specific functions
N Wettschureck et al.
PHYSIOLOGICAL REVIEWS (2005)
(D)-β-hydroxybutyrate inhibits adipocyte lipolysis via the nicotinic acid receptor PUMA-G
AKP Taggart et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Lactisole interacts with the transmembrane domains of human T1R3 to inhibit sweet taste
PH Jiang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
The FFA receptor GPR40 links hyperinsulinemia, hepatic steatosis, and impaired glucose homeostasis in mouse
R Steneberg et al.
CELL METABOLISM (2005)
A randomized trial of a strategy for increasing high-density lipoprotein cholesterol levels: Effects on progression of coronary heart disease and clinical events
EJ Whitney et al.
ANNALS OF INTERNAL MEDICINE (2005)
Free fatty acids regulate gut incretin glucagon-like peptide-1 secretion through GPR120
A Hirasawa et al.
NATURE MEDICINE (2005)
Short-chain fatty acids stimulate leptin production in adipocytes through the G protein-coupled receptor GPR41
YM Xiong et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
Different functional roles of T1R subunits in the heterorneric taste receptors
H Xu et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
Citric acid cycle intermediates as ligands for orphan G-protein-coupled receptors
WH He et al.
NATURE (2004)
The receptors for mammalian sweet and umami taste
GQ Zhao et al.
CELL (2003)
Pyrazole derivatives as partial Agonists for the nicotinic acid receptor
T van Herk et al.
JOURNAL OF MEDICINAL CHEMISTRY (2003)
Functional characterization of human receptors for short chain fatty acids and their role in polymorphonuclear cell activation
E Le Poul et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Identification of a free fatty acid receptor, FFA2R, expressed on leukocytes and activated by short-chain fatty acids
NE Nilsson et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2003)
The orphan G protein-coupled receptor GPR40 is activated by medium and long chain fatty acids
CP Briscoe et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
The orphan G protein-coupled receptors GPR41 and GPR43 are activated by propionate and other short chain carboxylic acids
AJ Brown et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Molecular identification of nicotinic acid receptor
T Soga et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2003)
Molecular identification of high and low affinity receptors for nicotinic acid
A Wise et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Free fatty acids regulate insulin secretion from pancreatic β cells through GPR40
Y Itoh et al.
NATURE (2003)
PUMA-G and HM74 are receptors for nicotinic acid and mediate its anti-lipolytic effect
S Tunaru et al.
NATURE MEDICINE (2003)
A human cell surface receptor activated by free fatty acids and thiazolidinedione drugs
K Kotarsky et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2003)
Coding of sweet, bitter, and umami tastes: Different receptor cells sharing similar signaling pathways
YF Zhang et al.
CELL (2003)
LSSIG is a novel murine leukocyte-specific GPCR that is induced by the activation of STAT3
T Senga et al.
BLOOD (2003)
The physiology of cellular liporegulation
RH Unger
ANNUAL REVIEW OF PHYSIOLOGY (2003)
Human receptors for sweet and umami taste
XD Li et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)
Simvastatin and niacin, antioxidant vitamins, or the combination for the prevention of coronary disease
BG Brown et al.
NEW ENGLAND JOURNAL OF MEDICINE (2001)
Mammalian sweet taste receptors
G Nelson et al.
CELL (2001)
cDNA representational difference analysis of human neutrophils stimulated by GM-CSF
S Yousefi et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2000)
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