相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。TRIAL WATCH PCSK9 antibody reduces LDL cholesterol
Sarah Crunkhorn
NATURE REVIEWS DRUG DISCOVERY (2012)
The biology and therapeutic targeting of the proprotein convertases
Nabil G. Seidah et al.
NATURE REVIEWS DRUG DISCOVERY (2012)
Conformation-Sensing Antibodies Stabilize the Oxidized Form of PTP1B and Inhibit Its Phosphatase Activity
Aftabul Haque et al.
CELL (2011)
The development of activating and inhibiting camelid VHH domains against human protein kinase C epsilon
Milla M. I. Paalanen et al.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (2011)
Phase I Study of Navitoclax (ABT-263), a Novel Bcl-2 Family Inhibitor, in Patients With Small-Cell Lung Cancer and Other Solid Tumors
Leena Gandhi et al.
JOURNAL OF CLINICAL ONCOLOGY (2011)
Fragment-based lead discovery: challenges and opportunities
Chaohong Sun et al.
JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN (2011)
Constraining Enzyme Conformational Change by an Antibody Leads to Hyperbolic Inhibition
David Oyen et al.
JOURNAL OF MOLECULAR BIOLOGY (2011)
Crystal Structure of the Amyloid-β p3 Fragment Provides a Model for Oligomer Formation in Alzheimer's Disease
Victor A. Streltsov et al.
JOURNAL OF NEUROSCIENCE (2011)
Structures of a key interaction protein from the Trypanosoma brucei editosome in complex with single domain antibodies
Meiting Wu et al.
JOURNAL OF STRUCTURAL BIOLOGY (2011)
Fragment Growing Induces Conformational Changes in Acetylcholine-Binding Protein: A Structural and Thermodynamic Analysis
Ewald Edink et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2011)
Structure of a nanobody-stabilized active state of the β2 adrenoceptor
Soren G. F. Rasmussen et al.
NATURE (2011)
A portable RNA sequence whose recognition by a synthetic antibody facilitates structural determination
Yelena Koldobskaya et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2011)
Allosteric control of ligand-binding affinity using engineered conformation-specific effector proteins
Shahir S. Rizk et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2011)
Atomic structure of a nanobody-trapped domain-swapped dimer of an amyloidogenic β2-microglobulin variant
Katarzyna Domanska et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
Turning a protein kinase on or off from a single allosteric site via disulfide trapping
Jack D. Sadowsky et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
Conversion of scFv peptide-binding specificity for crystal chaperone development
Jennifer C. Pai et al.
PROTEIN ENGINEERING DESIGN & SELECTION (2011)
Crystallization and preliminary X-ray diffraction analysis of a specific VHH domain against mouse prion protein
Romany N. N. Abskharon et al.
ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS (2010)
Structural and mechanistic insight into how antibodies inhibit serine proteases
Rajkumar Ganesan et al.
BIOCHEMICAL JOURNAL (2010)
Structural biology in fragment-based drug design
Christopher W. Murray et al.
CURRENT OPINION IN STRUCTURAL BIOLOGY (2010)
A Single-Domain Llama Antibody Potently Inhibits the Enzymatic Activity of Botulinum Neurotoxin by Binding to the Non-Catalytic α-Exosite Binding Region
Jianbo Dong et al.
JOURNAL OF MOLECULAR BIOLOGY (2010)
Structure and Properties of a Complex of α-Synuclein and a Single-Domain Camelid Antibody
Erwin J. De Genst et al.
JOURNAL OF MOLECULAR BIOLOGY (2010)
Small-molecule inhibitors of MDM2 as new anticancer therapeutics
Michael P. Dickens et al.
SEMINARS IN CANCER BIOLOGY (2010)
Substrate-dependent modulation of enzyme activity by allosteric effector antibodies
John N. Barlow et al.
BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS (2009)
Nanobody-aided structure determination of the EpsI:EpsJ pseudopilin heterodimer from Vibrio vulnificus
Anita Y. Lam et al.
JOURNAL OF STRUCTURAL BIOLOGY (2009)
Single-domain antibodies recognize selectively small oligomeric forms of amyloid β, prevent Aβ-induced neurotoxicity and inhibit fibril formation
Pierre Lafaye et al.
MOLECULAR IMMUNOLOGY (2009)
The rise of fragment-based drug discovery
Christopher W. Murray et al.
NATURE CHEMISTRY (2009)
Two-state selection of conformation-specific antibodies
Junjun Gao et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Unraveling the Allosteric Mechanism of Serine Protease Inhibition by an Antibody
Rajkumar Ganesan et al.
STRUCTURE (2009)
Crystal Structure of the N-Terminal Domain of the Secretin GspD from ETEC Determined with the Assistance of a Nanobody
Konstantin V. Korotkov et al.
STRUCTURE (2009)
High-Throughput Screening for High Affinity Antibodies
Simon Tickle et al.
JALA (2009)
Fragment-Based Screening Using Surface Plasmon Resonance Technology
Samantha Perspicace et al.
JOURNAL OF BIOMOLECULAR SCREENING (2009)
In vivo selection of intrabodies specifically targeting protein-protein interactions: A general platform for an undruggable class of disease targets
Michela Visintin et al.
JOURNAL OF BIOTECHNOLOGY (2008)
Toward chaperone-assisted crystallography:: Protein engineering enhancement of crystal packing and X-ray phasing capabilities of a camelid single-domain antibody (VHH) scaffold
Valentina Tereshko et al.
PROTEIN SCIENCE (2008)
Label-free primary screening and affinity ranking of fragment libraries using parallel analysis of protein panels
Markku D. Hamalainen et al.
JOURNAL OF BIOMOLECULAR SCREENING (2008)
Reaching for high-hanging fruit in drug discovery at protein-protein interfaces
James A. Wells et al.
NATURE (2007)
Directed selection of a conformational antibody domain that prevents mature amyloid fibril formation by stabilizing Aβ protofibrils
Gernot Habicht et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Structure-based discovery of an inhibitor of Arf activation by Sec7 domains through targeting of protein-protein complexes
Julien Viaud et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
A decade of fragment-based drug design: strategic advances and lessons learned
Philip J. Hajduk et al.
NATURE REVIEWS DRUG DISCOVERY (2007)
Targeting protein-protein interactions with small molecules: Challenges and perspectives for computational binding epitope detection and ligand finding
Domingo Gonzalez-Ruiz et al.
CURRENT MEDICINAL CHEMISTRY (2006)
Consolidating the set of known human protein-protein interactions in preparation for large-scale mapping of the human interactome
AK Ramani et al.
GENOME BIOLOGY (2005)
Small-molecule inhibitors of protein-protein interactions: Progressing towards the dream
MR Arkin et al.
NATURE REVIEWS DRUG DISCOVERY (2004)
Allosteric inhibition through core disruption
JR Horn et al.
JOURNAL OF MOLECULAR BIOLOGY (2004)
Is allostery an intrinsic property of all dynamic proteins?
K Gunasekaran et al.
PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS (2004)
Intracellular antibodies and challenges facing their use as therapeutic agents
MN Lobato et al.
TRENDS IN MOLECULAR MEDICINE (2003)
A camelid antibody fragment inhibits the formation of amyloid fibrils by human lysozyme
M Dumoulin et al.
NATURE (2003)
Crystal structure of the intrinsically flexible addiction antidote MazE
R Loris et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Mutations in PCSK9 cause autosomal dominant hypercholesterolemia
M Abifadel et al.
NATURE GENETICS (2003)
Crystal structure of ARF1 center dot Sec7 complexed with brefeldin A and its implications for the guanine nucleotide exchange mechanism
E Mossessova et al.
MOLECULAR CELL (2003)
Unraveling hot spots in binding interfaces: progress and challenges
WL DeLano
CURRENT OPINION IN STRUCTURAL BIOLOGY (2002)
Allosteric binding sites on cell-surface receptors: Novel targets for drug discovery
A Christopoulos
NATURE REVIEWS DRUG DISCOVERY (2002)
Chemistry of ion coordination and hydration revealed by a K+ channel-Fab complex at 2.0 Å resolution
YF Zhou et al.
NATURE (2001)
Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells
SM Elbashir et al.
NATURE (2001)