期刊
NATURE REVIEWS DRUG DISCOVERY
卷 10, 期 3, 页码 209-219出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nrd3366
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资金
- National Institutes of Health [AG10435]
- Veterans Administration
- Alzheimer's Association
- Shiley Family Foundation
- Dr Miriam and Sheldon G. Adelson Medical Research Foundation
The growth factor brain-derived neurotrophic factor (BDNF) and its receptor tropomyosin-related kinase receptor type B (TRKB) are actively produced and trafficked in multiple regions in the adult brain, where they influence neuronal activity, function and survival throughout life. The diverse presence and activity of BDNF suggests a potential role for this molecule in the pathogenesis and treatment of both neurological and psychiatric disorders. This article reviews the current understanding and future directions in BDNF-related research in the central nervous system, with an emphasis on the possible therapeutic application of BDNF in modifying fundamental processes underlying neural disease.
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