期刊
NATURE REVIEWS DRUG DISCOVERY
卷 10, 期 1, 页码 47-60出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nrd3320
关键词
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资金
- Associazione Italiana Ricerca sul Cancro [8925/2010]
- Ministero dell'Istruzione, dell'Universita e della Ricerca [2008PK2WCW/2008]
G protein-coupled receptors (GPCRs) belong to a superfamily of cell surface signalling proteins that have a pivotal role in many physiological functions and in multiple diseases, including the development of cancer and cancer metastasis. Current drugs that target GPCRs-many of which have excellent therapeutic benefits-are directed towards only a few GPCR members. Therefore, huge efforts are currently underway to develop new GPCR-based drugs, particularly for cancer. We review recent findings that present unexpected opportunities to interfere with major tumorigenic signals by manipulating GPCR-mediated pathways. We also discuss current data regarding novel GPCR targets that may provide promising opportunities for drug discovery in cancer prevention and treatment.
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