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ALZHEIMERS & DEMENTIA (2011)
The Brain-Derived Neurotrophic Factor Val66Met Polymorphism and Prediction of Neural Risk for Alzheimer Disease
Aristotle N. Voineskos et al.
ARCHIVES OF GENERAL PSYCHIATRY (2011)
Treadmill exercise prevents decline in spatial learning and memory in APP/PS1 transgenic mice through improvement of hippocampal long-term potentiation
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BEHAVIOURAL BRAIN RESEARCH (2011)
Reversal of autophagy dysfunction in the TgCRND8 mouse model of Alzheimer's disease ameliorates amyloid pathologies and memory deficits
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BRAIN (2011)
Disease-modifying properties of long-term lithium treatment for amnestic mild cognitive impairment: randomised controlled trial
Orestes V. Forlenza et al.
BRITISH JOURNAL OF PSYCHIATRY (2011)
Kynurenine 3-Monooxygenase Inhibition in Blood Ameliorates Neurodegeneration
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CELL (2011)
Mammalian Target of Rapamycin (mTOR) Inhibitors Potential Uses and a Review of Haematological Adverse Effects
Sofia Sofroniadou et al.
DRUG SAFETY (2011)
Altered palmitoylation and neuropathological deficits in mice lacking HIP14
Roshni R. Singaraja et al.
HUMAN MOLECULAR GENETICS (2011)
Wild-type HTT modulates the enzymatic activity of the neuronal palmitoyl transferase HIP14
Kun Huang et al.
HUMAN MOLECULAR GENETICS (2011)
Abnormal mitochondrial dynamics, mitochondrial loss and mutant huntingtin oligomers in Huntington's disease: implications for selective neuronal damage
Ulziibat Shirendeb et al.
HUMAN MOLECULAR GENETICS (2011)
Huntington's Disease: Effect of Memantine on FDG-PET Brain Metabolism?
L. E. Hjermind et al.
JOURNAL OF NEUROPSYCHIATRY AND CLINICAL NEUROSCIENCES (2011)
Soluble Aβ Oligomers Inhibit Long-Term Potentiation through a Mechanism Involving Excessive Activation of Extrasynaptic NR2B-Containing NMDA Receptors
Shaomin Li et al.
JOURNAL OF NEUROSCIENCE (2011)
Tau-Induced Defects in Synaptic Plasticity, Learning, and Memory Are Reversible in Transgenic Mice after Switching Off the Toxic Tau Mutant
Astrid Sydow et al.
JOURNAL OF NEUROSCIENCE (2011)
Amyloid-β/Fyn-Induced Synaptic, Network, and Cognitive Impairments Depend on Tau Levels in Multiple Mouse Models of Alzheimer's Disease
Erik D. Roberson et al.
JOURNAL OF NEUROSCIENCE (2011)
Intraneuronal Amyloid β Oligomers Cause Cell Death Via Endoplasmic Reticulum Stress, Endosomal/Lysosomal Leakage, and Mitochondrial Dysfunction In Vivo
Tomohiro Umeda et al.
JOURNAL OF NEUROSCIENCE RESEARCH (2011)
Biological and clinical changes in premanifest and early stage Huntington's disease in the TRACK-HD study: the 12-month longitudinal analysis
Sarah J. Tabrizi et al.
LANCET NEUROLOGY (2011)
Aβ1-42 inhibition of LTP is mediated by a signaling pathway involving caspase-3, Akt1 and GSK-3β
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NATURE NEUROSCIENCE (2011)
Ubiquitin-like protein conjugation and the ubiquitin-proteasome system as drug targets
Lynn Bedford et al.
NATURE REVIEWS DRUG DISCOVERY (2011)
The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics
Eric Karran et al.
NATURE REVIEWS DRUG DISCOVERY (2011)
Nicotinamide improves motor deficits and upregulates PGC-1 alpha and BDNF gene expression in a mouse model of Huntington's disease
Tyisha Hathorn et al.
NEUROBIOLOGY OF DISEASE (2011)
Deconstruction for Reconstruction: The Role of Proteolysis in Neural Plasticity and Disease
Baris Bingol et al.
NEURON (2011)
Subchronic memantine administration on spatial learning, exploratory activity, and nest-building in an APP/PS1 mouse model of Alzheimer's disease
Mohammed Filali et al.
NEUROPHARMACOLOGY (2011)
Gene Therapy in Mouse Models of Huntington Disease
Amber L. Southwell et al.
NEUROSCIENTIST (2011)
A Phase II Multi-Center Study of Triple Therapy with Paclitaxel, S-1 and Cisplatin in Patients with Advanced Gastric Cancer
H. Iwase et al.
ONCOLOGY (2011)
Beclin 1 Complex in Autophagy and Alzheimer Disease
Philipp A. Jaeger et al.
ARCHIVES OF NEUROLOGY (2010)
Genetically engineered mesenchymal stem cells reduce behavioral deficits in the YAC 128 mouse model of Huntington's disease
Nicholas D. Dey et al.
BEHAVIOURAL BRAIN RESEARCH (2010)
Dendritic Function of Tau Mediates Amyloid-β Toxicity in Alzheimer's Disease Mouse Models
Lars M. Ittner et al.
CELL (2010)
Activation of Specific Apoptotic Caspases with an Engineered Small-Molecule-Activated Protease
Daniel C. Gray et al.
CELL (2010)
Lysosomal Proteolysis and Autophagy Require Presenilin 1 and Are Disrupted by Alzheimer-Related PS1 Mutations
Ju-Hyun Lee et al.
CELL (2010)
Caspase-3 Activation via Mitochondria Is Required for Long-Term Depression and AMPA Receptor Internalization
Zheng Li et al.
CELL (2010)
Effects of the main green tea polyphenol epigallocatechin-3-gallate on cardiac involvement in patients with AL amyloidosis
Derliz Mereles et al.
CLINICAL RESEARCH IN CARDIOLOGY (2010)
The Physiological Relevance of Protein Phosphatase 1 and its Interacting Proteins to Health and Disease
M. Fardilha et al.
CURRENT MEDICINAL CHEMISTRY (2010)
The clinical development of histone deacetylase inhibitors as targeted anticancer drugs
Paul A. Marks
EXPERT OPINION ON INVESTIGATIONAL DRUGS (2010)
Advances and perspectives from genetic research: development of biological markers in Alzheimer's disease
Thomas Zetzsche et al.
EXPERT REVIEW OF MOLECULAR DIAGNOSTICS (2010)
Molecular mechanisms of neurodegeneration in Alzheimer's disease
Leslie Crews et al.
HUMAN MOLECULAR GENETICS (2010)
Nanolipidic particles improve the bioavailability and α-secretase inducing ability of epigallocatechin-3-gallate (EGCG) for the treatment of Alzheimer's disease
Adam Smith et al.
INTERNATIONAL JOURNAL OF PHARMACEUTICS (2010)
Huntingtin-associated Protein-1 Interacts with Pro-brain-derived Neurotrophic Factor and Mediates Its Transport and Release
Linda Lin-yan Wu et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
Phosphorylation of APP-CTF-AICD domains and interaction with adaptor proteins: signal transduction and/or transcriptional role - relevance for Alzheimer pathology
Gennaro Schettini et al.
JOURNAL OF NEUROCHEMISTRY (2010)
Convergence of Presenilin- and Tau-Mediated Pathways on Axonal Trafficking and Neuronal Function
Erica Peethumnongsin et al.
JOURNAL OF NEUROSCIENCE (2010)
Phosphorylation of Huntingtin at Ser421 in YAC128 Neurons Is Associated with Protection of YAC128 Neurons from NMDA-Mediated Excitotoxicity and Is Modulated by PP1 and PP2A
Martina Metzler et al.
JOURNAL OF NEUROSCIENCE (2010)
Activation of Extrasynaptic, But Not Synaptic, NMDA Receptors Modifies Amyloid Precursor Protein Expression Pattern and Increases Amyloid-β Production
Karim Bordji et al.
JOURNAL OF NEUROSCIENCE (2010)
Epothilone D Improves Microtubule Density, Axonal Integrity, and Cognition in a Transgenic Mouse Model of Tauopathy
Kurt R. Brunden et al.
JOURNAL OF NEUROSCIENCE (2010)
Identification of Caspase-6-Mediated Processing of the Valosin Containing Protein (p97) in Alzheimer's Disease: A Novel Link to Dysfunction in Ubiquitin Proteasome System-Mediated Protein Degradation
Dalia Halawani et al.
JOURNAL OF NEUROSCIENCE (2010)
Cleavage at the 586 Amino Acid Caspase-6 Site in Mutant huntingtin Influences Caspase-6 Activation In Vivo
Rona K. Graham et al.
JOURNAL OF NEUROSCIENCE (2010)
Axonal Degeneration Is Regulated by the Apoptotic Machinery or a NAD+-Sensitive Pathway in Insects and Mammals
Zohar Schoenmann et al.
JOURNAL OF NEUROSCIENCE (2010)
Mutant Huntingtin and Glycogen Synthase Kinase 3-beta Accumulate in Neuronal Lipid Rafts of a Presymptomatic Knock-In Mouse Model of Huntington's Disease
Antonio Valencia et al.
JOURNAL OF NEUROSCIENCE RESEARCH (2010)
From sentencing to execution - the processes of apoptosis
Kelly L. Moffitt et al.
JOURNAL OF PHARMACY AND PHARMACOLOGY (2010)
Activation of Wnt signaling by lithium and rosiglitazone reduced spatial memory impairment and neurodegeneration in brains of an APPswe/PSEN1ΔE9 mouse model of Alzheimer's disease
E. M. Toledo et al.
MOLECULAR PSYCHIATRY (2010)
Enhancement of proteasome activity by a small-molecule inhibitor of USP14
Byung-Hoon Lee et al.
NATURE (2010)
Autophagy gone awry in neurodegenerative diseases
Esther Wong et al.
NATURE NEUROSCIENCE (2010)
p75NTR-dependent, myelin-mediated axonal degeneration regulates neural connectivity in the adult brain
Katya J. Park et al.
NATURE NEUROSCIENCE (2010)
Protein palmitoylation in neuronal development and synaptic plasticity
Yuko Fukata et al.
NATURE REVIEWS NEUROSCIENCE (2010)
Early Increase in Extrasynaptic NMDA Receptor Signaling and Expression Contributes to Phenotype Onset in Huntington's Disease Mice
Austen J. Milnerwood et al.
NEURON (2010)
Novel Insights into Lithium's Mechanism of Action: Neurotrophic and Neuroprotective Effects
Jorge A. Quiroz et al.
NEUROPSYCHOBIOLOGY (2010)
Molecular Mechanisms and Potential Therapeutical Targets in Huntington's Disease
Chiara Zuccato et al.
PHYSIOLOGICAL REVIEWS (2010)
Inhibition of mTOR by Rapamycin Abolishes Cognitive Deficits and Reduces Amyloid-beta Levels in a Mouse Model of Alzheimer's Disease
Patricia Spilman et al.
PLOS ONE (2010)
Complete Phenotypic Recovery of an Alzheimer's Disease Model by a Quinone-Tryptophan Hybrid Aggregation Inhibitor
Roni Scherzer-Attali et al.
PLOS ONE (2010)
A small-molecule scaffold induces autophagy in primary neurons and protects against toxicity in a Huntington disease model
Andrey S. Tsvetkov et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Genome-wide analysis reveals mechanisms modulating autophagy in normal brain aging and in Alzheimer's disease
Marta M. Lipinski et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Early deficits in synaptic mitochondria in an Alzheimer's disease mouse model
Heng Du et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Biology of Amyloid: Structure, Function, and Regulation
Jason Greenwald et al.
STRUCTURE (2010)
Dopamine D1 receptor-mediated NMDA receptor insertion depends on Fyn but not Src kinase pathway in prefrontal cortical neurons
Jian-Li Hu et al.
MOLECULAR BRAIN (2010)
Huntington's disease
Marianne J. U. Novak et al.
BMJ-BRITISH MEDICAL JOURNAL (2010)
Selective Vulnerability in Alzheimer's Disease: Amyloid Precursor Protein and p75NTR Interaction
Joanna Fombonne et al.
ANNALS OF NEUROLOGY (2009)
Can't live without them, can live with them: roles of caspases during vital cellular processes
Yael Feinstein-Rotkopf et al.
APOPTOSIS (2009)
Development of a Non Invasive NGF-Based Therapy for Alzheimer's Disease
Sonia Covaceuszach et al.
CURRENT ALZHEIMER RESEARCH (2009)
Early Diagnosis of Alzheimer's Disease: Is MCI Too Late?
Ronald C. Petersen
CURRENT ALZHEIMER RESEARCH (2009)
Mouse models of Huntington disease: variations on a theme
Dagmar E. Ehrnhoefer et al.
DISEASE MODELS & MECHANISMS (2009)
Neuronal palmitoyl acyl transferases exhibit distinct substrate specificity
Kun Huang et al.
FASEB JOURNAL (2009)
S-Palmitoylation of γ-Secretase Subunits Nicastrin and APH-1
Haipeng Cheng et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
Single Neuron Ubiquitin-Proteasome Dynamics Accompanying Inclusion Body Formation in Huntington Disease
Siddhartha Mitra et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
The Effects of Amyloid Precursor Protein on Postsynaptic Composition and Activity
Hyang-Sook Hoe et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
Lithium Trial in Alzheimer's Disease: A Randomized, Single-Blind, Placebo-Controlled, Multicenter 10-Week Study
Harald Hampel et al.
JOURNAL OF CLINICAL PSYCHIATRY (2009)
Apoptosis and cancer: mutations within caspase genes
S. Ghavami et al.
JOURNAL OF MEDICAL GENETICS (2009)
Beclin 1 Gene Transfer Activates Autophagy and Ameliorates the Neurodegenerative Pathology in α-Synuclein Models of Parkinson's and Lewy Body Diseases
Brian Spencer et al.
JOURNAL OF NEUROSCIENCE (2009)
Phosphorylation of huntingtin reduces the accumulation of its nuclear fragments
Simon C. Warby et al.
MOLECULAR AND CELLULAR NEUROSCIENCE (2009)
Mutant Huntingtin Impairs Post-Golgi Trafficking to Lysosomes by Delocalizing Optineurin/Rab8 Complex from the Golgi Apparatus
Daniel del Toro et al.
MOLECULAR BIOLOGY OF THE CELL (2009)
APP binds DR6 to trigger axon pruning and neuron death via distinct caspases
Anatoly Nikolaev et al.
NATURE (2009)
Balance between synaptic versus extrasynaptic NMDA receptor activity influences inclusions and neurotoxicity of mutant huntingtin
Shu-ichi Okamoto et al.
NATURE MEDICINE (2009)
Neuroprotective effects of brain-derived neurotrophic factor in rodent and primate models of Alzheimer's disease
Alan H. Nagahara et al.
NATURE MEDICINE (2009)
A novel GSK-3 beta inhibitor reduces Alzheimer's pathology and rescues neuronal loss in vivo
L. Sereno et al.
NEUROBIOLOGY OF DISEASE (2009)
Phenylbutyrate Ameliorates Cognitive Deficit and Reduces Tau Pathology in an Alzheimer's Disease Mouse Model
Ana Ricobaraza et al.
NEUROPSYCHOPHARMACOLOGY (2009)
Recombinant human NGF-loaded microspheres promote survival of basal forebrain cholinergic neurons and improve memory impairments of spatial learning in the rat model of Alzheimer's disease with fimbria-fornix lesion
Haigang Gu et al.
NEUROSCIENCE LETTERS (2009)
Neural stem cells improve cognition via BDNF in a transgenic model of Alzheimer disease
Mathew Blurton-Jones et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Up-regulating BDNF with an ampakine rescues synaptic plasticity and memory in Huntington's disease knockin mice
Danielle A. Simmons et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Evidence of Oxidative Stress in Alzheimer's Disease Brain and Antioxidant Therapy Lights and Shadows
Domenico Pratico
MITOCHONDRIA AND OXIDATIVE STRESS IN NEURODEGENERATIVE DISORDERS (2008)
Evidence of Oxidant Damage in Huntington's Disease: Translational Strategies Using Antioxidants
Edward C. Stack et al.
MITOCHONDRIA AND OXIDATIVE STRESS IN NEURODEGENERATIVE DISORDERS (2008)
Green tea epigallocatechin-3-gallate (EGCG) reduces β-amyloid mediated cognitive impairment and modulates tau pathology in Alzheimer transgenic mice
Kavon Rezai-Zadeh et al.
BRAIN RESEARCH (2008)
Neurotrophins - From Pathophysiology to Treatment in Alzheimers Disease
Rainer Hellweg et al.
Current Alzheimer Research (2008)
Impaired ubiquitin-proteasome system activity in the synapses of Huntington's disease mice
Jianjun Wang et al.
JOURNAL OF CELL BIOLOGY (2008)
The ubiquitin-proteasome system in Alzheimer's disease
Salvatore Oddo
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2008)
Valproic acid inhibits Aβ production, neuritic plaque formation, and behavioral deficits in Alzheimer's disease mouse models
Hong Qing et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2008)
Novel targets for Huntington's disease in an mTOR-independent autophagy pathway
Andrea Williams et al.
NATURE CHEMICAL BIOLOGY (2008)
EGCG redirects amyloidogenic polypeptides into unstructured, off-pathway oligomers
Dagmar E. Ehrnhoefer et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2008)
Protective effect of BDNF against beta-amyloid induced neurotoxicity in vitro and in vivo in rats
S. Arancibia et al.
NEUROBIOLOGY OF DISEASE (2008)
Activation of Trk neurotrophin receptors by glucocorticoids provides a neuroprotective effect
Freddy Jeanneteau et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Differential regulation of dynein and kinesin motor proteins by tau
Ram Dixit et al.
SCIENCE (2008)
Systematic assessment of BDNF and its receptor levels in human cortices affected by Huntington's disease
Chiara Zuccato et al.
BRAIN PATHOLOGY (2008)
The ubiquitin proteasome system in Huntington's disease and the spinocerebellar ataxias
Janet E. Davies et al.
BMC BIOCHEMISTRY (2007)
Small molecule enhancers of rapamycin-induced TOR inhibition promote autophagy, reduce toxicity in Huntington's disease models and enhance killing of mycobacteria by macrophages
R. Andres Floto et al.
AUTOPHAGY (2007)
N-phenylamine derivatives as aggregation inhibitors in cell models of Tauopathy
A. Pickhardt et al.
CURRENT ALZHEIMER RESEARCH (2007)
Impairments in fast axonal transport and motor neuron deficits in transgenic mice expressing familial Alzheimer's disease-linked mutant presenilin 1
Orly Lazarov et al.
JOURNAL OF NEUROSCIENCE (2007)
Dopamine-depen dent long term potentiation in the dorsal striatum is reduced in the R6/2 mouse model of Huntington's disease
V. W. S. Kung et al.
NEUROSCIENCE (2007)
Microtubule-stabilizing agent prevents protein accumulation-induced loss of synaptic markers
David Butler et al.
EUROPEAN JOURNAL OF PHARMACOLOGY (2007)
Neuroprotection by Hsp104 and Hsp27 in lentiviral-based rat models of Huntington's disease
Valerie Perrin et al.
MOLECULAR THERAPY (2007)
Neurotrophins and their receptors: roles in plasticity, neurodegeneration and neuroprotection
A. Hennigan et al.
BIOCHEMICAL SOCIETY TRANSACTIONS (2007)
Activation of caspase-6 in aging and mild cognitive impairment
Steffen Albrecht et al.
AMERICAN JOURNAL OF PATHOLOGY (2007)
Histone deacetylase 6 inhibition compensates for the transport deficit in Huntington's disease by increasing tubulin acetylation
Jim P. Dompierre et al.
JOURNAL OF NEUROSCIENCE (2007)
UP inhibits LTD in the hippocampus via regulation of GSK3β
Stephane Peineau et al.
NEURON (2007)
Neuroprotective effects of regulators of the glycogen synthase kinase-3β signaling pathway in a transgenic model of Alzheimer's disease are associated with reduced amyloid precursor protein phosphorylation
Edward Rockenstein et al.
JOURNAL OF NEUROSCIENCE (2007)
A pilot study of the clinical efficacy and safety of memantine for Huntington's disease
William G. Ondo et al.
PARKINSONISM & RELATED DISORDERS (2007)
A placebo-controlled trial of valproate for agitation and aggression in Alzheimer's disease
Nathan Herrmann et al.
DEMENTIA AND GERIATRIC COGNITIVE DISORDERS (2007)
Brain-derived neurotrophic factor does not influence age at neurologic onset of Huntington's disease
Shotaro Kishikawa et al.
NEUROBIOLOGY OF DISEASE (2006)
Green tea (-)-epigallocatechin-gallate modulates early events in huntingtin misfolding and reduces toxicity in Huntington's disease models
Dagmar E. Ehrnhoefer et al.
HUMAN MOLECULAR GENETICS (2006)
Anti-amyloidogenic therapies: strategies for prevention and treatment of Alzheimer's disease
T. Hamaguchi et al.
CELLULAR AND MOLECULAR LIFE SCIENCES (2006)
Cleavage at the caspase-6 site is required for neuronal dysfunction and degeneration due to mutant huntingtin
Rona K. Graham et al.
CELL (2006)
Palmitoylation of huntingtin by HIP14 is essential for its trafficking and function
Anat Yanai et al.
NATURE NEUROSCIENCE (2006)
Regulation of Intracellular Accumulation of Mutant Huntingtin by Beclin 1
Mamoru Shibata et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Reversal of Alzheimer's-like pathology and behavior in human APP transgenic mice by mutation of Asp664
V Galvan et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Association between CSF biomarkers and incipient Alzheimer's disease in patients with mild cognitive impairment: a follow-up study
O Hansson et al.
LANCET NEUROLOGY (2006)
Autophagy-mediated clearance of huntingtin aggregates triggered by the insulin-signaling pathway
A Yamamoto et al.
JOURNAL OF CELL BIOLOGY (2006)
Interaction of huntingtin-associated protein-1 with kinesin light chain - Implications in intracellular trafficking in neurons
JR McGuire et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Association analysis of brain-derived neurotrophic factor (BDNF) gene 196 A/G polymorphism with Alzheimer's disease (AD) in mainland Chinese
HT Bian et al.
NEUROSCIENCE LETTERS (2005)
Macroautophagy -: a novel β-amyloid peptide-generating pathway activated in Alzheimer's disease
WH Yu et al.
JOURNAL OF CELL BIOLOGY (2005)
Investigation of the effect of brain-derived neurotrophic factor (BDNF) polymorphisms on the risk of late-onset Alzheimer's disease (AD) and quantitative measures of AD progression
P Desai et al.
NEUROSCIENCE LETTERS (2005)
A phase 1 clinical trial of nerve growth factor gene therapy for Alzheimer disease
MH Tuszynski et al.
NATURE MEDICINE (2005)
A potent small molecule inhibits polyglutamine aggregation in Huntington's disease neurons and suppresses neurodegeneration in vivo
XQ Zhang et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
Brain-derived neurotrophic factor genetic variants are not susceptibility factors to Alzheimer's disease in Italy
S Bagnoli et al.
ANNALS OF NEUROLOGY (2004)
Active caspase-6 and caspase-6-cleaved Tau in neuropil threads, neuritic plaques, and neurofibrillary tangles of Alzheimer's disease
HS Guo et al.
AMERICAN JOURNAL OF PATHOLOGY (2004)
Huntingtin controls neurotrophic support and survival of neurons by enhancing BDNF vesicular transport along microtubules
LR Gauthier et al.
CELL (2004)
Protein aggregation and neurodegenerative disease
CA Ross et al.
NATURE MEDICINE (2004)
Suppression of the caspase cleavage of β-amyloid precursor protein by its cytoplasmic phosphorylation
H Taru et al.
FEBS LETTERS (2004)
Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease
B Ravikumar et al.
NATURE GENETICS (2004)
Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death
M Arrasate et al.
NATURE (2004)
Polymorphism at codon 66 of the brain-derived neurotrophic factor gene is not associated with sporadic Alzheimer's disease
O Combarros et al.
DEMENTIA AND GERIATRIC COGNITIVE DISORDERS (2004)
Autophagy regulates the processing of amino terminal huntingtin fragments
ZH Qin et al.
HUMAN MOLECULAR GENETICS (2003)
Chronic activation of ERK and neurodegenerative diseases
L Colucci-D'Amato et al.
BIOESSAYS (2003)
Expression of polyglutamine-expanded huntingtin induces tyrosine phosphorylation of N-methyl-D-aspartate receptors
C Song et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
The hunt for huntingtin function: interaction partners tell many different stories
P Harjes et al.
TRENDS IN BIOCHEMICAL SCIENCES (2003)
An Alzheimer's disease hypothesis based on transcriptional dysregulation
NK Robakis
AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS (2003)
GSK-3α regulates production of Alzheimer's disease amyloid-β peptides
CJ Phiel et al.
NATURE (2003)
Suberoylanilide hydroxamic acid, a histone deacetylase inhibitor, ameliorates motor deficits in a mouse model of Huntington's disease
E Hockly et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
Glycogen synthase kinase-3β inhibitors prevent cellular polyglutamine toxicity caused by the Huntington's disease mutation
J Carmichael et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Mechanisms of p75-mediated death of hippocampal neurons - Role of caspases
CM Troy et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Mice overexpressing 70-kDa heat shock protein show increased resistance to malonate and 3-nitropropionic acid
A Dedeoglu et al.
EXPERIMENTAL NEUROLOGY (2002)
The IGF-1/Akt pathway is neuroprotective in Huntington's disease and involves huntingtin phosphorylation by Akt
S Humbert et al.
DEVELOPMENTAL CELL (2002)
Neuron number in the entorhinal cortex and CA1 in preclinical Alzheimer disease
JL Price et al.
ARCHIVES OF NEUROLOGY (2001)
Post-translational processing of β-secretase (β-amyloid-converting enzyme) and its ectodomain shedding -: The pro- and transmembrane/cytosolic domains affect its cellular activity and amyloid-β production
S Benjannet et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Inhibition of huntingtin fibrillogenesis by specific antibodies and small molecules: Implications for Huntington's disease therapy
V Heiser et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)
Brain-derived neurotrophic factor in Huntington disease
I Ferrer et al.
BRAIN RESEARCH (2000)
Intracerebral implantation of NGF-releasing biodegradable microspheres protects striatum against excitotoxic damage
P Menei et al.
EXPERIMENTAL NEUROLOGY (2000)