期刊
NATURE REVIEWS DRUG DISCOVERY
卷 8, 期 5, 页码 417-429出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nrd2476
关键词
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资金
- Juvenile Diabetes Research Foundation
- National Institutes of Health
- National Health and Medical Research Council of Australia
- Medical Research Service of the Department of Veterans Affairs
Long-term diabetes increases the likelihood of developing secondary damage to numerous systems, and these complications represent a substantial cause of morbidity and mortality. Establishing the causes of diabetes remains the key step towards eradicating the disease, but the prevention and amelioration of diabetic complications is equally important for the millions of individuals who already have the disease or are likely to develop it before prophylaxis or a cure become routinely available. In this Review, we focus on four common complications of diabetes, discuss the range of pathologies that are precipitated by hyperglycaemia and highlight emerging targets for therapeutic intervention.
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