期刊
NATURE REVIEWS DRUG DISCOVERY
卷 8, 期 12, 页码 982-1001出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nrd2983
关键词
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资金
- National Institute of Health [RO1 GM076063]
- Max-Planck Society
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM076063] Funding Source: NIH RePORTER
The human genome encodes 40 voltage-gated K+ channels (K-V), which are involved in diverse physiological processes ranging from repolarization of neuronal and cardiac action potentials, to regulating Ca2+ signalling and cell volume, to driving cellular proliferation and migration. K-V channels offer tremendous opportunities for the development of new drugs to treat cancer, autoimmune diseases and metabolic, neurological and cardiovascular disorders. This Review discusses pharmacological strategies for targeting K-V channels with venom peptides, antibodies and small molecules, and highlights recent progress in the preclinical and clinical development of drugs targeting the K(V)1 subfamily, the K(V)7 subfamily (also known as KCNQ), K(V)10.1 (also known as EAG1 and KCNH1) and K(V)11.1 (also known as HERG and KCNH2) channels.
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