期刊
NATURE REVIEWS DRUG DISCOVERY
卷 7, 期 11, 页码 900-907出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nrd2684
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资金
- US National Institutes of Health
- NIH
- Wellcome Trust
- European Bioinformatics Institute
- US NIH/National Institute of Allergy and Infectious Diseases
- United Nations Development Programme/World Bank/World Health Organization Special Programme
The increasing availability of genomic data for pathogens that cause tropical diseases has created new opportunities for drug discovery and development. However, if the potential of such data is to be fully exploited, the data must be effectively integrated and be easy to interrogate. Here, we discuss the development of the TDR Targets database (http://tdrtargets.org), which encompasses extensive genetic, biochemical and pharmacological data related to tropical disease pathogens, as well as computationally predicted druggability for potential targets and compound desirability information. By allowing the integration and weighting of this information, this database aims to facilitate the identification and prioritization of candidate drug targets for pathogens.
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