期刊
NATURE REVIEWS CLINICAL ONCOLOGY
卷 11, 期 10, 页码 566-584出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nrclinonc.2014.126
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资金
- National Cancer Institute, NIH, US Department of Human and Health Services [NCT00254943, T32-CA009502, NCT00756106, NCT00662506, S10 RR021110-01A1, P01CA80124]
- South-Eastern Norway Regional Health Authority [2013069]
- Sigrid Juselius Foundation
- Instrumentarium Research Foundation
- Academy of Finland
- Paulo Foundation
- Finnish Medical Foundation
Our understanding of the importance of blood vessels and angiogenesis in cancer has increased considerably over the past decades, and the assessment of tumour vessel calibre and structure has become increasingly important for in vivo monitoring of therapeutic response. The preferred method for in vivo imaging of most solid cancers is MRI, and the concept of vessel-calibre MRI has evolved since its initial inception in the early 1990s. Almost a quarter of a century later, unlike traditional contrast-enhanced MRI techniques, vessel-calibre MRI remains widely inaccessible to the general clinical community. The narrow availability of the technique is, in part, attributable to limited awareness and a lack of imaging standardization. Thus, the role of vessel-calibre MRI in early phase clinical trials remains to be determined. By contrast, regulatory approvals of antiangiogenic agents that are not directly cytotoxic have created an urgent need for clinical trials incorporating advanced imaging analyses, going beyond traditional assessments of tumour volume. To this end, we review the field of vessel-calibre MRI and summarize the emerging evidence supporting the use of this technique to monitor response to anticancer therapy. We also discuss the potential use of this biomarker assessment in clinical imaging trials and highlight relevant avenues for future research.
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