期刊
NATURE REVIEWS CLINICAL ONCOLOGY
卷 7, 期 2, 页码 83-89出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nrclinonc.2009.219
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资金
- Cancer Reasearch UK
- Ministry of Education of the Czech Republic [MSM 0021620808]
- European Society of Medical Oncology
- Cancer Research UK
- Department of Health
- Cancer Research UK [12011] Funding Source: researchfish
Members of the nuclear receptor superfamily are ligand-regulated transcription factors involved in the control of a broad range of normal physiological and disease processes. The estrogen receptor alpha (ER alpha) is a member of the steriod receptor family, which is part of the nuclear receptor superfamily. ER alpha it is important for many biological processes and plays a key role in the pathogenesis of breast cancer. Gene regulation by ER alpha requires the recruitment of a multitude of transcriptional co-regulators to the promoters of estrogen-responsive genes. There is evidence in support of the involvement of these co-regulators in breast cancer progression. We review the role of steroid receptor co-activator-3 (SRC-3), which is frequently amplified in breast cancer, and its role in breast cancer risk, outcome and response to endocrine therapy in patients with breast cancer.
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