期刊
NATURE REVIEWS CARDIOLOGY
卷 11, 期 9, 页码 516-529出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nrcardio.2014.91
关键词
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资金
- European Union [TOLERAGE HEALTH-F4-2008-202156]
- Austrian Research Fund (FWF) [P198810-B05]
- Medizinische Forschungsforderung Innsbruck MFI [9443]
- Lore and Udo Saldow-Donation
- Tiroler Wissenschaftsfonds Project The role of Vascular Associated Lymphoid Tissue (VALT) in the Development of Atherosclerosis-Inside Out or Outside In
- Translational Research Project T-Oral
Atherosclerosis is a chronic, multifactorial disease that starts in youth, manifests clinically later in life, and can lead to myocardial infarction, stroke, claudication, and death. Although inflammatory processes have long been known to be involved in atherogenesis, interest in this subject has grown in the past 30-40 years. Animal experiments and human analyses of early atherosclerotic lesions have shown that the first pathogenic event in atherogenesis is the intimal infiltration of T cells at arterial branching points. These T cells recognize heat shock protein (HSP)60, which is expressed together with adhesion molecules by endothelial cells in response to classic risk factors for atherosclerosis. Although these HSP60-reactive T cells initiate atherosclerosis, antibodies to HSP60 accelerate and perpetuate the disease. All healthy humans develop cellular and humoral immunity against microbial HSP60 by infection or vaccination. Given that prokaryotic (bacterial) and eukaryotic (for instance, human) HSP60 display substantial sequence homology, atherosclerosis might be the price we pay for this protective immunity, if risk factors stress the vascular endothelial cells beyond physiological conditions.
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