期刊
SMALL
卷 11, 期 35, 页码 4517-4525出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/smll.201500997
关键词
Ag2S QDs; dual modality nanoprobes; nanoprobes; image-guided surgery; magnetic resonance imaging; near-infrared fluorescence
类别
资金
- Chinese Academy of Sciences [XDA01030200]
- Ministry of Science and Technology of China [2011CB965004]
- National Natural Science Foundation of China [21303249, 21301187, 21425103, 81401464]
- Natural Science Foundation of Jiangsu Province [BK2012007, BK20130366]
In clinical practice, it is difficult to identify tumor margins during brain surgery due to its inherent infiltrative character. Herein, a unique dual-modality nanoprobe (Gd-DOTA-Ag2S QDs, referred as Gd-Ag2S nanoprobe) is reported, which integrates advantages of the deep tissue penetration of enhanced magnetic resonance (MR) imaging of Gd and the high signal-to-noise ratio and high spatiotemporal resolution of fluorescence imaging in the second near-infrared window (NIR-II) of Ag2S quantum dots (QDs). Due to the abundant tumor angiogenesis and the enhanced permeability and retention effect in the tumor, a brain tumor (U87MG) in a mouse model is clearly delineated in situ with the help of the Gd assisted T1 MR imaging and the intraoperative resection of the tumor is precisely accomplished under the guidance of NIR-II fluorescence imaging of Ag2S QDs after intravenous injection of Gd-Ag2S nanoprobe. Additionally, no histologic changes are observed in the main organs of the mouse after administration of Gd-Ag2S nanoprobe for 1 month, indicating the high biocompatibility of the nanoprobe. We expect that such a novel Detection and Operation strategy based on Gd-Ag2S nanoprobe is promising in future clinical applications.
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