期刊
NATURE PROTOCOLS
卷 7, 期 4, 页码 637-642出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nprot.2012.011
关键词
-
资金
- US National Institutes of Health [R01DE017088, N01-AI-30041]
Oropharyngeal candidiasis is a frequent cause of morbidity in patients with defects in cell-mediated immunity or saliva production. Animal models of this infection are important for studying disease pathogenesis and evaluating vaccines and antifungal therapies. Here we describe a simple mouse model of oropharyngeal candidiasis. Mice are rendered susceptible to oral infection by injection with cortisone acetate and then inoculated by placing a swab saturated with Candida albicans sublingually. This process results in a reproducible level of infection, the histopathology of which mimics that of pseudomembranous oropharyngeal candidiasis in humans. By using this model, data are obtained after 5-9 d of work.
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