期刊
SMALL
卷 11, 期 31, 页码 3807-3813出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/smll.201500155
关键词
metal-organic frameworks; pillarene; supramolecular switches; targeted drug release; drug delivery; Zn2+ triggers
类别
资金
- National Natural Science Foundation of China [21272093, 51473061]
- Fundamental Research Funds for the Central Universities [JCKY-QKJC05]
A new theranostic nanoplatform, comprising of monodisperse zirconium metal-organic frameworks (MOFs) as drug carriers and carboxylatopillar[5]arene-based supramolecular switches as gating entities, is constructed, and controlled drug release triggered by bio-friendly Zn2+ ions (abundant in synaptic vesicles) and auxiliary thermal stimulus is realized. This on-command drug delivery system exhibits large pore sizes for drug encapsulation, excellent biodegradability and biocompatibility, extremely low cytotoxicity and premature drug release, and superior dual-stimuli responsiveness, opening a new avenue in targeted drug delivery and controlled release of therapeutic agents, especially in the treatment of central nervous system diseases.
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