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注意:仅列出部分参考文献,下载原文获取全部文献信息。Next generation topoisomerase I inhibitors: Rationale and biomarker strategies
Beverly A. Teicher
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Mutations in topoisomerase I as a self-resistance mechanism coevolved with the production of the anticancer alkaloid camptothecin in plants
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Novel indenoisoquinolines NSC 725776 and NSC 724998 produce persistent topolsomerase I cleavage complexes and overcome multidrug resistance
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Nitrated indenoisoquinolines as topoisomerase I inhibitors: A systematic study and optimization
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Investigation of the lactam side chain length necessary for optimal indenoisoquinoline topoisomerase i inhibition and cytotoxicity in human cancer cell cultures
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Apoptosis is induced in leishmanial cells by a novel protein kinase inhibitor withaferin A and is facilitated by apoptotic topoisomerase I-DNA complex
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A. Rockstroh et al.
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A systematic study of nitrated indenoisoquinolines reveals a potent topoisomerase I inhibitor
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Topoisomerase II and tubulin inhibitors both induce the formation of apoptotic topoisomerase I cleavage complexes
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Bisindenoisoquinoline bis-1,3-{(5,6-dihydro-5,11-diketo-11H-indeno[1,2-c] isoquinoline)-6-propylamino}propane bis(trifluoroacetate) (NSC 727357), a DNA intercalator and topoisomerase inhibitor with antitumor activity
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Evaluation of indenoisoquinoline topoisomerase I inhibitors using a hollow fiber assay
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A novel norindenoisoquinoline structure reveals a common interfacial inhibitor paradigm for ternary trapping of the topoisomerase I-DNA covalent complex
C Marchand et al.
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Esters and amides of 2,3-dimethoxy-8,9-methylenedioxybenzo[i]phenanthridine-12-carboxylic acid:: Potent cytotoxic and topoisomerase I-targeting agents
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Synthesis and mechanism of action studies of a series of norindenoisoquinoline topoisomerase I poisons reveal an inhibitor with a flipped orientation in the ternary DNA-enzyme-inhibitor complex as determined by X-ray crystallographic analysis
A Ioanoviciu et al.
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Structures of three classes of anticancer agents bound to the human topoisomerase I-DNA covalent complex
BL Staker et al.
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Friction and torque govern the relaxation of DNA supercoils by eukaryotic topoisomerase IB
DA Koster et al.
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Defective DNA single-strand break repair in spinocerebellar ataxia with axonal neuropathy-1
SF El-Khamisy et al.
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Cellular topoisomerase I inhibition and antiproliferative activity by MJ-III-65 (NSC 706744), an indenoisoquinoline topoisomerase I poison
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Thirteen-exon-motif signature for vertebrate nuclear and mitochondrial type IB topoisomerases
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The human topoisomerase I damage response plays a role in apoptosis
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DNA REPAIR (2004)
Topoisomerase I-DNA complexes contribute to arsenic trioxide-induced apoptosis
O Sordet et al.
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Gimatecan, a novel camptothecin with a promising preclinical profile
G Pratesi et al.
ANTI-CANCER DRUGS (2004)
Apoptotic topoisomerase I-DNA complexes induced by staurosporine-mediated oxygen radicals
O Sordet et al.
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Position- and orientation-specific enhancement of topoisomerase I cleavage complexes by triplex DNA structures
S Antony et al.
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Enhancement of camptothecin-induced topoisomerase I cleavage complexes by the acetaldehyde adduct N-2-ethyl-2 '-deoxyguanosine
S Antony et al.
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Analysis of human topoisomerase I inhibition and interaction with the cleavage site+1 deoxyguanosine, via in vitro experiments and molecular modeling studies
GS Laco et al.
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Synthesis and pharmacological evaluation of novel non-lactone analogues of camptothecin
P Hautefaye et al.
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Structural impact of the leukemia drug 1-β-D-arabinofuranosyleytosine (Ara-C) on the covalent human topoisomerase I-DNA complex
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Homocamptothecins: potent topoisomerase I inhibitors and promising anticancer drugs
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CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY (2003)
The mechanism of topoisomerase I poisoning by a camptothecin analog
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8-oxoguanine rearranges the active site of human topoisomerase I
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Different effects on human topoisomerase I by minor groove and intercalated deoxyguanosine adducts derived from two polycyclic aromatic hydrocarbon diol epoxides at or near a normal cleavage site
Y Pommier et al.
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HL Zhang et al.
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Position-specific trapping of topoisomerase I-DNA cleavage complexes by intercalated benzo[a]pyrene diol epoxide adducts at the 6-amino group of adenine
Y Pommier et al.
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Essential functions of DNA topoisomerase I in Drosophila melanogaster
CX Zhang et al.
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Conversion of topoisomerase 1 cleavage complexes on the leading strand of ribosomal DNA into 5′-phosphorylated DNA double-strand breaks by replication runoff
D Strumberg et al.
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Benzo[a]pyrene diol epoxide adducts in DNA are potent suppressors of a normal topoisomerase I cleavage site and powerful inducers of other topoisomerase I cleavages
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