期刊
NATURE PHOTONICS
卷 5, 期 11, 页码 683-688出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/NPHOTON.2011.222
关键词
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资金
- European Project SMD [CP-FP 229375-2]
- Project NANOANTENNA FP7-HEALTH-2009 [241818]
- FIRB 'Rete Nazionale di Ricerca sulle Nanoscienze ItalNanoNet' [RBPR05JH2P_010]
The detection of a few molecules in a highly diluted solution is of paramount interest in fields including biomedicine, safety and eco-pollution in relation to rare and dangerous chemicals. Nanosensors based on plasmonics are promising devices in this regard, in that they combine the features of high sensitivity, label-free detection and miniaturization. However, plasmonic-based nanosensors, in common with general sensors with sensitive areas on the scale of nanometres, cannot be used directly to detect molecules dissolved in femto- or attomolar solutions. In other words, they are diffusion-limited and their detection times become impractical at such concentrations. In this Article, we demonstrate, by combining super-hydrophobic artificial surfaces and nanoplasmonic structures, that few molecules can be localized and detected even at attomolar (10(-18) mol l(-1)) concentration. Moreover, the detection can be combined with fluorescence and Raman spectroscopy, such that the chemical signature of the molecules can be clearly determined.
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