期刊
NATURE NEUROSCIENCE
卷 17, 期 12, 页码 1693-1700出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nn.3870
关键词
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资金
- VIB grant
- FWO grant [ZKC6058-00-W01]
- KUL-program financing IMIR [PF10/017]
- FRAXA
- Dutch Medical Research Council NWO VIDI [917.10.372]
- SAO
- Associazione Italians Sindrome X Fragile
- NEUROBRAINNET LAP [7/16]
- Flemish Methusalem grant
- Innovation Ingenio-Consolider
- [FWO-G.0705.11]
- [FWO-G.0667.09]
- [FWO-ZKC5858]
- [FWO-G0.666.10N]
Deficiencies in fragile X mental retardation protein (FMRP) are the most common cause of inherited intellectual disability, fragile X syndrome (FXS), with symptoms manifesting during infancy and early childhood. Using a mouse model for FXS, we found that Fmrp regulates the positioning of neurons in the cortical plate during embryonic development, affecting their multipolar-to-bipolar transition (MBT). We identified N-cadherin, which is crucial for MBT, as an Fmrp-regulated target in embryonic brain. Furthermore, spontaneous network activity and high-resolution brain imaging revealed defects in the establishment of neuronal networks at very early developmental stages, further confirmed by an unbalanced excitatory and inhibitory network. Finally, reintroduction of Fmrp or N-cadherin in the embryo normalized early postnatal neuron activity. Our findings highlight the critical role of Fmrp in the developing cerebral cortex and might explain some of the clinical features observed in patients with FXS, such as alterations in synaptic communication and neuronal network connectivity.
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