期刊
NATURE NEUROSCIENCE
卷 17, 期 11, 页码 1607-1612出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nn.3832
关键词
-
资金
- US National Institutes of Health [R01DA035484, R01MH076136]
- Canadian Institute of Health Research
- Fonds de Recherche en Sante du Quebec
- James S. McDonnell Foundation
Pain is a primary driver of learning and motivated action. It is also a target of learning, as nociceptive brain responses are shaped by learning processes. We combined an instrumental pain avoidance task with an axiomatic approach to assessing fMRI signals related to prediction errors (PEs), which drive reinforcement-based learning. We found that pain PEs were encoded in the periaqueductal gray (PAG), a structure important for pain control and learning in animal models. Axiomatic tests combined with dynamic causal modeling suggested that ventromedial prefrontal cortex, supported by putamen, provides an expected value-related input to the PAG, which then conveys PE signals to prefrontal regions important for behavioral regulation, including orbitofrontal, anterior mid-cingulate and dorsomedial prefrontal cortices. Thus, pain-related learning involves distinct neural circuitry, with implications for behavior and pain dynamics.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据